negative regulation of Notch signaling pathway involved in somitogenesis
multicellular organism development
T cell differentiation
compartment pattern specification
animal organ morphogenesis
ovarian follicle development
positive regulation of protein binding
regulation of Notch signaling pathway
positive regulation of Notch signaling pathway
positive regulation of meiotic cell cycle
protein O-linked fucosylation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3955
16848
Ensembl
ENSG00000106003
ENSMUSG00000029570
UniProt
Q8NES3
O09010
RefSeq (mRNA)
NM_002304 NM_001040167 NM_001040168 NM_001166355
NM_008494
RefSeq (protein)
NP_001035257 NP_001035258 NP_001159827 NP_002295
NP_032520
Location (UCSC)
Chr 7: 2.51 – 2.53 Mb
Chr 5: 140.59 – 140.6 Mb
PubMed search
[6]
[7]
Wikidata
View/Edit Human
View/Edit Mouse
This gene encodes a member of the glycosyltransferase superfamily. The encoded protein is a single-pass type II Golgi membrane protein that functions as a fucose-specific glycosyltransferase, adding an N-acetylglucosamine to the fucose residue of a group of signaling receptors involved in regulating cell fate decisions during development. Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Alternatively spliced transcript variants that encode different isoforms have been described, however, not all variants have been fully characterized.[3]
^"LFNG - Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe - Homo sapiens (Human) - LFNG gene & protein". www.uniprot.org. Retrieved 4 June 2022.
^Egan S, Herbrick JA, Tsui LC, Cohen B, Flock G, Beatty B, Scherer SW (December 1998). "Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12". Genomics. 54 (3): 576–7. doi:10.1006/geno.1998.5559. PMID 9878264.
fringe, also known as Lunatic Fringe, is a protein encoded in humans by the LFNG gene. This gene encodes a member of the glycosyltransferase superfamily....
activation turns on LFNG which in turn inhibits the Notch receptor. Notch activation also turns on the HES1 gene which inactivates LFNG, re-enabling the...
fanatical views, may refer to: "Lunatic Fringe" (song), a 1981 song by Red Rider LFNG, a gene in the Notch pathway Jon Moxley (born 1985), nicknamed "Lunatic Fringe"...
three genes associated to the mouse segmentation clock, (MESP2, DLL3 and LFNG), have been shown to be mutated in cases of congenital scoliosis, suggesting...
coordinate key steps in this process. In mice, mutations in Notch1, Dll1 or Dll3, Lfng, or Hes7 result in abnormal somite formation. Similarly, in humans, the following...
oscillatory manner. The HES7 protein also represses expression of Lunatic Fringe (LFNG) thereby both directly and indirectly regulating the Notch signalling pathway...
the manic fringe (MFNG), the radical fringe (RFNG) and lunatic fringe (LFNG) genes were identified in mammals. Fringe genes encode O-fucose specific...
and he contributed to subsequent research identifying mutations in the LFNG and HES7 genes for related congenital axial skeletal disorders. Kusumi is...
family which also includes the radical fringe (RFNG) and lunatic fringe (LFNG). They all encode evolutionarily conserved proteins that act in the Notch...
respectively. The ZLI is also characterized by a lack of lunatic fringe (lfng), which is observable even before Shh expression is observed in the forming...
Global Information
