The Kidd antigen system (also known as Jk antigen) are proteins found in the Kidd's blood group, which act as antigens, i.e., they have the ability to produce antibodies under certain circumstances. The Jk antigen is found on a protein responsible for urea transport in the red blood cells and the kidney.[1] They are important in transfusion medicine. People with two Jk(a) antigens, for instance, may form antibodies against donated blood containing two Jk(b) antigens (and thus no Jk(a) antigens). This can lead to hemolytic anemia, in which the body destroys the transfused blood, leading to low red blood cell counts. Another disease associated with the Jk antigen is hemolytic disease of the newborn, in which a pregnant woman's body creates antibodies against the blood of her fetus, leading to destruction of the fetal blood cells. Hemolytic disease of the newborn associated with Jk antibodies is typically mild, though fatal cases have been reported.[2]
The gene encoding this protein is found on chromosome 18.[3] Three Jk alleles are Jk (a), Jk (b)and Jk3. Jk (a) was discovered by Allen et al. in 1951 and is named after a patient (Mrs Kidd delivered a baby with a haemolytic disease of the newborn associated with an antibody directed against a new antigen Jk (a). Whereas Jk (b) was discovered by Plant et al. in 1953, individuals who lack the Jk antigen (Jk null) are unable to maximally concentrate their urine.[4]
^Olives B, Mattei MG, Huet M, Neau P, Martial S, Cartron JP, Bailly P. "Kidd blood group and urea transport function of human erythrocytes are carried by the same protein." Journal of Biological Chemistry. 1995 Jun 30;270(26):15607-10. doi:10.1074/jbc.270.26.15607 PMID 7797558
^Kim WD, Lee YH. "A fatal case of severe hemolytic disease of newborn associated with anti-Jk(b)." Journal of Korean Medical Science. 2006 Feb;21(1):151-4. PMID 16479082
^Geitvik GA, Hoyheim B, Gedde-Dahl T, Grzeschik KH, Lothe R, Tomter H, Olaisen B. "The Kidd (JK) blood group locus assigned to chromosome 18 by close linkage to a DNA-RFLP." Human Genetics. 1987 Nov;77(3):205-9. doi:10.1007/BF00284470 PMID 2890568
^Sands JM, Gargus JJ, Frohlich O, Gunn RB, Kokko JP. "Urinary concentrating ability in patients with Jk(a-b-) blood type who lack carrier-mediated urea transport." Journal of the American Society of Nephrology. 1992 Jun;2(12):1689-96. PMID 1498276
and 25 Related for: Kidd antigen system information
The Kiddantigensystem (also known as Jk antigen) are proteins found in the Kidd's blood group, which act as antigens, i.e., they have the ability to...
Duffy antigen/chemokine receptor (DARC), also known as Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234), is a protein that in humans is...
series), a 2006 Brazilian series about Juscelino Kubitschek Jk antigen, or Kiddantigensystem JK business, the practice of compensated dating with high school...
States, which held the call sign KIDD from 1957 to 1987 and from 1991 to 2021 KiddantigensystemKidd class destroyer Kidd Hall, a student housing cooperative...
group systems is defined by the International Society of Blood Transfusion (ISBT) as systems in the human species where cell-surface antigens—in particular...
glycoproteins, or glycolipids, depending on the blood group system. Some of these antigens are also present on the surface of other types of cells of various...
that are predominantly IgG, such as those directed towards antigens of the Duffy and Kiddsystems,: 198–200 generally do not cause immediate agglutination...
limited to the ABO, Rh, Kell, Duffy, Kidd, and MNS blood group systems. Antibodies to blood group systemantigens and their characteristics must be identified...
(DAT), is used to detect if antibodies or complement system factors have bound to RBCs surface antigens. The DAT is not required for pre-transfusion testing...
system. Hemolytic reactions may also be caused by incompatibilities with Rh factors, Duffy antigens, Kell antigens, Kiddantigens, and Lewis antigens...
recommends antigen testing to rule out the presence of HDN as the direct coombs can come back negative in a severely affected infant. Kiddantigens are also...
incompatibilities can cause AHTR, the most common of which is Kiddantigen incompatibility. Rh, Kell, and Duffy antigen incompatibility have also been implicated in AHTR...
transporter for exporting Lactic acid to the liver. See Cori cycle.; Kiddantigen protein – urea transporter; RHAG – gas transporter, probably of carbon...
based upon the ability of an antibody to bind specifically to an antigen. The antigen, usually a protein or carbohydrate made by an infectious agent, is...
physiological and biochemical processes, including membrane transport, antigen–antibody interactions, protein synthesis, oxidation reactions, actin–myosin...
defenses by up-regulating antigen presentation by virtue of increasing the expression of major histocompatibility complex (MHC) antigens. Certain symptoms of...
donor units must first be screened for the corresponding antigen by phenotyping them. Antigen negative units are then tested against the patient plasma...
and Duffy b, and enhances some other antigens including antigens from the Rh, Kidd, Lewis, I, and P1 systems. It is also used for cleaning the animal...
"Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk". Proceedings of the National...
transpeptidase and alkaline phosphatase levels). CA19-9 (carbohydrate antigen 19.9) is a tumor marker that is frequently elevated in pancreatic cancer...
an immature state. The cells are capable of sensing microbes as well as antigen capture and processing capabilities. A rapid accumulation of pulpal DCs...
areas. Blood tests for tumor markers, such as carcinoembryonic antigen and carbohydrate antigen may be ordered, as their levels correlate to extent of metastasis...
Global Information