KDM5D information

KDM5D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E6R, 2YQE
Identifiers
Aliases	KDM5D, HY, HYA, JARID1D, SMCY, lysine demethylase 5D
External IDs	OMIM: 426000 MGI: 99780 HomoloGene: 55838 GeneCards: KDM5D
Gene location (Human)
Chr.	Y chromosome (human)
End	19,744,939 bp
Gene location (Mouse)
Chr.	Y chromosome (mouse)
End	956,786 bp
RNA expression pattern
	Top expressed in
	rectum; ; right lung; ; prostate; ; urethra; ; trabecular bone; ; Brodmann area 9; ; corpus callosum; ; seminal vesicula; ; right adrenal gland; ; mucosa of urinary bladder;
	Top expressed in
	left lung lobe; ; internal carotid artery; ; external carotid artery; ; female urethra; ; male urethra; ; vas deferens; ; triceps brachii muscle; ; epithelium of stomach; ; digastric muscle; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone H3-methyl-lysine-4 demethylase activity; DNA binding; oxidoreductase activity; dioxygenase activity; metal ion binding; histone demethylase activity; androgen receptor binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding; histone H3-tri/di/monomethyl-lysine-4 demethylase activity; methylated histone binding;
Cellular component	nucleus; nucleoplasm; fibrillar center; cellular component; histone methyltransferase complex;
Biological process	histone H3-K4 demethylation; T cell antigen processing and presentation; transcription, DNA-templated; regulation of transcription, DNA-templated; regulation of androgen receptor signaling pathway; chromatin organization; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; histone H3-K4 demethylation, trimethyl-H3-K4-specific; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
	8284
	20592
	ENSG00000012817
	ENSMUSG00000056673
	Q9BY66
	Q62240
	NM_001146705; NM_001146706; NM_004653
	NM_011419
	NP_001140177; NP_001140178; NP_004644
	NP_035549
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine-specific demethylase 5D is an enzyme that in humans is encoded by the KDM5D gene.^[5]^[6]^[7] KDM5D belongs to the alpha-ketoglutarate-dependent hydroxylases superfamily.

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000012817 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056673 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Froggatt P (Feb 1977). "The foundation of the "Inst" medical department and its association with the Belfast Fever Hospital". The Ulster Medical Journal. 45 (2): 107–45. PMC 2385577. PMID 795123.
^ Kent-First MG, Maffitt M, Muallem A, Brisco P, Shultz J, Ekenberg S, Agulnik AI, Agulnik I, Shramm D, Bavister B, Abdul-Mawgood A, VandeBerg J (October 1996). "Gene sequence and evolutionary conservation of human SMCY". Nature Genetics. 14 (2): 128–9. doi:10.1038/ng1096-128. PMID 8841177. S2CID 23054699.
^ ^a ^b "Entrez Gene: JARID1D jumonji, AT rich interactive domain 1D".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000012817 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056673 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid795123-5] Froggatt P (Feb 1977). "The foundation of the "Inst" medical department and its association with the Belfast Fever Hospital". The Ulster Medical Journal. 45 (2): 107–45. PMC 2385577. PMID 795123.

[pmid8841177-6] Kent-First MG, Maffitt M, Muallem A, Brisco P, Shultz J, Ekenberg S, Agulnik AI, Agulnik I, Shramm D, Bavister B, Abdul-Mawgood A, VandeBerg J (October 1996). "Gene sequence and evolutionary conservation of human SMCY". Nature Genetics. 14 (2): 128–9. doi:10.1038/ng1096-128. PMID 8841177. S2CID 23054699.

[entrez-7] "Entrez Gene: JARID1D jumonji, AT rich interactive domain 1D".

KDM5D information

and 5 Related for: KDM5D information

KDM5D

Y chromosome

Azoospermia factor

Demethylase

Philip Kantoff