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Iohexol information


Iohexol
Clinical data
Trade namesOmnipaque, Hexopaque, Oraltag, others
Other names5-[N-(2,3-Dihydroxypropyl)acetamido]-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide
AHFS/Drugs.comMicromedex Detailed Consumer Information
License data
  • US DailyMed: Iohexol
Routes of
administration
Intrathecal, intravascular, by mouth, intracavital, rectal
ATC code
  • V08AB02 (WHO)
Legal status
Legal status
  • CA: ℞-only[2][3]
  • US: WARNING[1]Rx-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein bindingLow
MetabolismNil
Elimination half-lifeVariable
ExcretionKidney, unchanged
Identifiers
IUPAC name
  • 1-N,3-N-Bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide
CAS Number
  • 66108-95-0 checkY
PubChem CID
  • 3730
DrugBank
  • DB01362 checkY
ChemSpider
  • 3599 checkY
UNII
  • 4419T9MX03
KEGG
  • D01817 checkY
ChEBI
  • CHEBI:31709 checkY
ChEMBL
  • ChEMBL1200455 ☒N
CompTox Dashboard (EPA)
  • DTXSID6023157 Edit this at Wikidata
ECHA InfoCard100.060.130 Edit this at Wikidata
Chemical and physical data
FormulaC19H26I3N3O9
Molar mass821.142 g·mol−1
3D model (JSmol)
  • Interactive image
Melting point174 to 180 °C (345 to 356 °F)
SMILES
  • O=C(N(c1c(I)c(c(I)c(c1I)C(=O)NCC(O)CO)C(=O)NCC(O)CO)CC(O)CO)C
InChI
  • InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34) checkY
  • Key:NTHXOOBQLCIOLC-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Iohexol, sold under the trade name Omnipaque among others, is a contrast agent used for X-ray imaging.[4] This includes when visualizing arteries, veins, ventricles of the brain, the urinary system, and joints, as well as during computed tomography (CT scan).[4] It is given by mouth, injection into a vein, or into a body cavity.[5]

Side effects include vomiting, skin flushing, headache, itchiness, kidney problems, and low blood pressure.[4] Less commonly allergic reactions or seizures may occur.[4] Allergies to povidone-iodine or shellfish do not affect the risk of side effects more than other allergies.[6] Use in the later part of pregnancy may cause hypothyroidism in the baby.[7] Iohexol is an iodinated non-ionic radiocontrast agent.[4] It is in the low osmolar family.[8]

Iohexol was approved for medical use in 1985.[9] It is on the World Health Organization's List of Essential Medicines.[10][5]

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  2. ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
  3. ^ "Regulatory Decision Summary for Omnipaque". Drug and Health Products Portal. 29 December 2023. Retrieved 2 April 2024.
  4. ^ a b c d e World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 317–8. hdl:10665/44053. ISBN 9789241547659.
  5. ^ a b Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 171. ISBN 9781284057560.
  6. ^ ACR Manual on Contrast Media v10.3. 2017 (PDF). American College of Radiology. 2017. p. 6. ISBN 9781559030120. Archived (PDF) from the original on 1 January 2018. Retrieved 1 January 2018.
  7. ^ Briggs GG, Freeman RK, Yaffe SJ (2011). Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins. p. 761. ISBN 9781608317080. Archived from the original on 1 January 2017.
  8. ^ Sutton D, Young JW (2012). A Short Textbook of Clinical Imaging. Springer Science & Business Media. p. 235. ISBN 9781447117551. Archived from the original on 1 January 2017.
  9. ^ Broe ME, Porter GA, Bennett WM, Verpooten GA (2013). Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals. Springer Science & Business Media. p. 325. ISBN 9789401590884. Archived from the original on 1 January 2017.
  10. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

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Iohexol

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Iohexol, sold under the trade name Omnipaque among others, is a contrast agent used for X-ray imaging. This includes when visualizing arteries, veins...

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WHO Model List of Essential Medicines

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benzoate Permethrin Fluorescein Tropicamide Amidotrizoate Barium sulfate Iohexol Complementary: Barium sulfateα Meglumine iotroxateα Chlorhexidine Ethanol...

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Iodinated contrast

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"dense" the X-ray effect. Organic iodine molecules used for contrast include iohexol, iodixanol, and ioversol. Iodine-based contrast media used nowadays are...

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Gemfibrozil

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selected emerging micropollutants sucralose, Acesulfame-K, gemfibrozil, and iohexol in a karst spring during a multi-event spring response". Journal of Contaminant...

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Radiocontrast agent

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(intravenous urography) Organic iodine molecules used for contrast include iohexol, iodixanol and ioversol. Barium sulfate is mainly used in the imaging of...

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Inulin

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GFR. These measures, which involve clearance of such substrates as EDTA, iohexol, cystatin C, 125I-iothalamate (sodium radioiothalamate), the chromium radioisotope...

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Schedule H

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HUMAN 251. INTERFERON 252. INTRAVENOUS FAT EMULSION 253. IOBITRIDOL 254. IOHEXOL 255. IOPAMIDOL 4 256. IOMEPROL 257. IOPROMIDE 258. IRBESARTAN 259. IRINOTECAN...

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Sulfur hexafluoride

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Iocarmic acid Methiodal Diodone Nephrotropic, low osmolar Metrizamide Iohexol# Ioxaglic acid Iopamidol Iopromide Iotrolan Ioversol Iopentol Iodixanol...

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Ammonium ferric citrate

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Iocarmic acid Methiodal Diodone Nephrotropic, low osmolar Metrizamide Iohexol# Ioxaglic acid Iopamidol Iopromide Iotrolan Ioversol Iopentol Iodixanol...

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Beilu Pharmaceutical

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The company mainly produces gadopentetate dimeglumine injections, and Iohexol injections. Beilu Pharma is headquartered in Beijing, and was financed...

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Glomerular filtration rate

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reactions including a fatal outcome. Consequently, the contrast agents Iohexol and Iothalamate have become more popular alternatives to determine GFR...

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ATC code V08

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Iocarmic acid V08AA09 Methiodal V08AA10 Diodone V08AB01 Metrizamide V08AB02 Iohexol V08AB03 Ioxaglic acid V08AB04 Iopamidol V08AB05 Iopromide V08AB06 Iotrolan...

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Lumbar provocative discography

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contraindicated for this procedure. Non-ionic contrast media such as iopamidol and iohexol are used. Needles are inserted through the back into the disc near the...

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Cystatin C

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51chromium-EDTA, 125I-iothalamate, 99mTc-DTPA or radiocontrast agents such as iohexol, but these techniques are complicated, costly, time-consuming and have...

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Tedral

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Clarithromycin Erythromycin Interleukin-6 (IL-6) inhibiting therapies Iohexol Levothyroxine Methotrexate Quinine Verapamil Zafirlukast Theophylline cause...

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Iopentol

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concluded that iopentol produces images of a similarly high quality as iohexol, and that it is equally well tolerated by patients. After intravenous injection...

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Sympathicolysis

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houses the lumbar sympathetic ganglion. Then, iodinated contrast medium (iohexol) and lignociane is injected into the target site to check the position...

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Iobitridol

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low– or medium–osmolarity iodinated contrast agents such as iopamidol or iohexol. After intravenous infusion, iobitridol is distributed in the circulatory...

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Ioglicic acid

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"Haemodynamic side effects of meglumine ioglicate, meglumine sodium ioxaglate and iohexol in aortofemoral angiography: comparison of a high-osmolar and two low-osmolar...

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Environmental xenobiotic

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Metoprolol Propanolol Betaxolol Bisoprolol Nadolol Iopromide Iopamidol Iohexol Diatrizoate Cyclophosphamide Mycophenolic acid Ifosfamide Bicalutamide...

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Metrizoic acid

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PMID 9204361. S2CID 27742637. Zachrisson BE, Jagenburg R (1983). "Comparison of iohexol with metrizoate in urography. A single blind parallel investigation". Acta...

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