Infliximab, a chimeric monoclonal antibody, sold under the brand name Remicade among others, is a medication used to treat a number of autoimmune diseases. This includes Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, and Behçet's disease.[13] It is given by slow injection into a vein, typically at six- to eight-week intervals.[13]
Common side effects include infections, acute infusion reactions, and abdominal pain.[13] Infliximab is a chimeric monoclonal antibody biologic. It seems to work by binding to and neutralizing TNF-α, preventing it from interacting with its receptors on the cell.[13] TNF-α is a chemical messenger (cytokine) and a key part of the autoimmune reaction.
Infliximab was originally developed in mice as a mouse antibody. Because humans have immune reactions to mouse proteins, the mouse common domains were replaced with similar human antibody domains. They are monoclonal antibodies and have identical structures and affinities to the target. Because they are a combination of mouse and human antibody amino acid sequences, they are called a "chimeric monoclonal antibody".[14][medical citation needed]
Infliximab was approved for medical use in the United States in 1998,[13] and in the European Union in August 1999.[15] Infliximab biosimilars have been approved in the EU (2013), in Japan (2014), and in the United States (2016, 2017, 2019).[1][4][2] It is on the World Health Organization's List of Essential Medicines.[16]
^ abcCite error: The named reference Renflexis FDA approval was invoked but never defined (see the help page).
^ abcCite error: The named reference Avsola FDA approval was invoked but never defined (see the help page).
^ abCite error: The named reference Inflectra FDA approval was invoked but never defined (see the help page).
^ abcCite error: The named reference Ixifi FDA approval was invoked but never defined (see the help page).
^ abc"Health Canada New Drug Authorizations: 2016 Highlights". Health Canada. 14 March 2017. Archived from the original on 7 April 2024. Retrieved 7 April 2024.
^"Arthritis". Health Canada. 8 May 2018. Retrieved 13 April 2024.
^"Regulatory Decision Summary for Renflexis". Drug and Health Products Portal. 1 December 2017. Retrieved 13 April 2024.
^Cite error: The named reference Zymfentra PR was invoked but never defined (see the help page).
^"Infliximab Use During Pregnancy". Drugs.com. 2 July 2019. Archived from the original on 30 November 2020. Retrieved 13 August 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^"Health product highlights 2021: Annexes of products approved in 2021". Health Canada. 3 August 2022. Archived from the original on 25 March 2024. Retrieved 25 March 2024.
^"Regulatory Decision Summary for Remsima SC". Drug and Health Products Portal. 15 February 2024. Archived from the original on 2 April 2024. Retrieved 2 April 2024.
^ abcde"Infliximab, Infliximab-dyyb Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 15 July 2019. Retrieved 15 July 2019.
^Mouser JF, Hyams JS (June 1999). "Infliximab: a novel chimeric monoclonal antibody for the treatment of Crohn's disease". Clinical Therapeutics. 21 (6): 932–42, discussion 931. doi:10.1016/s0149-2918(99)80015-0. PMID 10440618.
^"Remicade EPAR". European Medicines Agency (EMA). Archived from the original on 22 October 2020. Retrieved 2 April 2020.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
Infliximab, a chimeric monoclonal antibody, sold under the brand name Remicade among others, is a medication used to treat a number of autoimmune diseases...
of a monoclonal antibody to be approved worldwide was a biosimilar of infliximab in the EU in 2013. On March 6, 2015, the FDA approved the United States'...
not infectious. Treatments may include corticosteroids, ciclosporin, infliximab, or canakinumab. The disease was identified in 1930. It affects approximately...
1988, a monoclonal antibody called infliximab was discovered at New York University's School of Medicine. Infliximab works by binding to TNF, stopping...
Inhibition of TNF effects can be achieved with a monoclonal antibody such as infliximab, adalimumab, certolizumab pegol, and golimumab, or with a circulating...
such as infliximab from binding antigen in a laboratory test. Specifically, neutralization occurs when the anti-drug antibody binds to infliximab's antigen...
(disease-modifying antirheumatic drugs), monoclonal antibodies, such as infliximab and adalimumab, the TNF inhibitor etanercept, and methotrexate for moderate...
allergies, azathioprine and antibodies, including mepolizumab, omalizumab, infliximab, and adalimumab. The word enteritis (/ˌɛntəˈraɪtɪs/) uses combining forms...
Trastuzumab Monoclonal antibodies used for autoimmune diseases include infliximab and adalimumab, which are effective in rheumatoid arthritis, Crohn's disease...
molecules (e.g., atorvastatin, fluticasone, clopidogrel) and "biologics" (infliximab, erythropoietin, insulin glargine), the latter of which are most often...
inhibitor. This inhibition can be achieved with a monoclonal antibody such as infliximab (Remicade) binding directly to TNF, adalimumab (Humira), certolizumab...
active disease. Use of certain medications, such as corticosteroids and infliximab (an anti-αTNF monoclonal antibody), is another important risk factor,...
immune cells. Monoclonal antibodies used for autoimmune diseases include infliximab and adalimumab, which are effective in rheumatoid arthritis, Crohn's disease...
incorporates parts of multiple different antibodies, for example, in the case of infliximab, variable (binding) regions from a mouse anti-TNF antibody and constant...
with long-term use. Tumor necrosis factor (TNF)-alpha inhibitors like infliximab (Remicade) and adalimumab (Humira) have shown promise for some, but they...
and should be avoided. Certolizumab pegol, etanercept, golimumab and infliximab are alternatives, including quality-assured biosimilars Afatinib and gefitinib...
similar to that seen with infliximab, but as adalimumab has better tolerability profile it may be preferred over infliximab. Ursodeoxycholic acid has...
fistulas will need surgery to fix. Medications such as antibiotics and Infliximab may be prescribed to help close the rectovaginal fistula or prepare for...
binding protein is a monoclonal antibody or a circulating receptor such as infliximab (Remicade), etanercept (Enbrel), or adalimumab (Humira) that binds to...
Biologics prescribed for psoriatic arthritis are TNF-α inhibitors, including infliximab, etanercept, golimumab, certolizumab pegol and adalimumab, as well as...
anti-inflammatory drugs (e.g. celecoxib) -mab for monoclonal antibodies (e.g. infliximab); see Nomenclature of monoclonal antibodies -nab- for cannabinoid receptor...
both created and entirely funded by a drug company, to promote Remicade (Infliximab). In 2008, Centocor, Inc. and Ortho Biotech Inc. merged to form Centocor...
Global Information
(what is this?) (verify)