Low magnification micrograph of an inflammatory fibroid polyp. H&E stain.
Specialty
Gastroenterology
An inflammatory fibroid polyp(IFP) is an uncommon digestive system tumor.[1] J. Vanek initially identified it as a separate pathological entity in 1949 when he reported six case reports of eosinophilic infiltration in gastric submucosal granulomas.[2] It is a single, non-encapsulated polypoid lesion that is typically submucosal. It is characterized by a large number of small blood vessels, oedematous connective tissue, and an inflammatory eosinophilic infiltrate.[3]
Inflammatory fibroid polyp has also been referred to as polypoid myo-endothelioma,[4] fibroma with eosinophilic infiltration,[5] inflammatory pseudotumour,[5] myxoma,[6] haemangiopericytoma,[7] eosinophilic granuloma,[5] Vanek's tumour,[8] and gastric eosinophilic submucosal granuloma.[2]
When the lesions are symptomatic, they typically measure less than 3 cm in size and are linked to symptoms such as iron deficiency anemia, bleeding, weight loss, and dyspeptic symptoms. Significant complications like obstruction, intussusception, and even hypovolemic shock can result from larger lesions.[9]
^Cite error: The named reference Inflammatory fibroid polyp of the oesophagus was invoked but never defined (see the help page).
^ abJ, Vanek (1949). "Gastric submucosal granuloma with eosinophilic infiltration". The American Journal of Pathology. 25 (3). Am J Pathol: 397–411. ISSN 0002-9440. PMC 1942901. PMID 18127133.
^Cite error: The named reference Inflammatory fibroid polyps of the duodenum: a review of the literature was invoked but never defined (see the help page).
^Cite error: The named reference histogenesis was invoked but never defined (see the help page).
^ abcCite error: The named reference General Case of the Day was invoked but never defined (see the help page).
^Cite error: The named reference Fibrous inflammatory polyps of the ileum was invoked but never defined (see the help page).
^Cite error: The named reference Johnstone Morson 1978 pp. 349–361 was invoked but never defined (see the help page).
^Daum, Ondrej; Hes, Ondrej; Vanecek, Tomas; Benes, Zdenek; Sima, Radek; Zamecnik, Michal; Mukensnabl, Petr; Hadravska, Sarka; Curik, Romuald; Michal, Michal (2003). "Vanek's tumor (inflammatory fibroid polyp). Report of 18 cases and comparison with three cases of original Vanek's series". Annals of Diagnostic Pathology. 7 (6). Elsevier BV: 337–347. doi:10.1016/j.anndiagpath.2003.09.003. ISSN 1092-9134. PMID 15018116.
^Maccagno, Andrea; Sander, Björn; Dintner, Sebastian; Harloff, Manuela; Füzesi, László; Märkl, Bruno (2023). "Inflammatory fibroid polyp: A series of 29 cases and a systematic review of the literature". Human Pathology Reports. 32. Elsevier BV: 300703. doi:10.1016/j.hpr.2023.300703. ISSN 2772-736X.
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