The immunome is the set of genes that code for proteins which constitute the immune system, excluding those that are widespread in other cell types, and not involved in the immune response itself.[1][2] It is further defined as the set of peptides derived from the proteome that interact with the immune system.[3] There are numerous ongoing efforts to characterize and sequence the immunomes of humans, mice, and elements of non-human primates. Typically, immunomes are studied using immunofluorescence microscopy to determine the presence and activity of immune-related enzymes and pathways.[4]
Practical applications for studying the immunome include vaccines, therapeutic proteins, and further treatment of other diseases.[3][5] The study of the immunome falls under the field of immunomics.
^Ortutay, Csaba; Vihinen, Mauno (2009). "Immunome Knowledge Base (IKB): An integrated service for immunome research". BMC Immunology. 10 (3): 3. doi:10.1186/1471-2172-10-3. PMC 2632617. PMID 19134210.
^"IAVI Report - Prepping for the Immunome". Iavireport.org. Retrieved April 25, 2016.
^ abDe Groot, Anne (1 December 2009). "Exploring the immunome: A brave new world for human vaccine development". Human Vaccines. 5 (12): 790–793. doi:10.4161/hv.10683. PMC 2919815. PMID 20009527.
^Biancotto, A; McCoy, JP (2014). "Studying the Human Immunome: The Complexity of Comprehensive Leukocyte Immunophenotyping". Curr. Top. Microbiol. Immunol. Current Topics in Microbiology and Immunology. 377: 23–60. doi:10.1007/82_2013_336. ISBN 978-3-642-54826-0. PMC 4184245. PMID 23975032.
^Snyder, William (22 September 2017). "Cracking the Code of the Immune System". Vanderbilt Medicine Magazine. Vanderbilt University. Retrieved 1 May 2020.
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