IPO7 information

IPO7
Identifiers
Aliases	IPO7, Imp7, RANBP7, importin 7
External IDs	OMIM: 605586 MGI: 2152414 HomoloGene: 4659 GeneCards: IPO7
Gene location (Human)
Chr.	Chromosome 11 (human)
End	9,448,127 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	109,655,816 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; lower lobe of lung; ; triceps brachii muscle; ; deltoid muscle; ; caput epididymis; ; tibialis anterior muscle; ; body of tongue; ; corpus epididymis; ; thoracic diaphragm; ; pericardium;
	Top expressed in
	parotid gland; ; temporal muscle; ; digastric muscle; ; abdominal wall; ; triceps brachii muscle; ; lacrimal gland; ; sternocleidomastoid muscle; ; primitive streak; ; medial ganglionic eminence; ; right ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	histone binding; protein binding; GTPase regulator activity; transporter activity; SMAD binding;
Cellular component	nuclear pore; membrane; nucleus; nucleoplasm; cytoplasm; cytosol; nuclear envelope;
Biological process	protein transport; innate immune response; viral process; intracellular protein transport; signal transduction; regulation of catalytic activity; protein import into nucleus; transport; negative regulation of cyclin-dependent protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	10527
	233726
	ENSG00000205339
	ENSMUSG00000066232
	O95373
	Q9EPL8
	NM_006391
	NM_181517; NM_001362172
	NP_006382
	NP_852658; NP_001349101
	Wikidata
View/Edit Human	View/Edit Mouse

Importin-7 is a protein that in humans is encoded by the IPO7 gene.^[5]^[6]

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000205339 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066232 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gorlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E (Aug 1997). "A novel class of RanGTP binding proteins". J Cell Biol. 138 (1): 65–80. doi:10.1083/jcb.138.1.65. PMC 2139951. PMID 9214382.
^ ^a ^b "Entrez Gene: IPO7 importin 7".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000205339 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066232 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9214382-5] Gorlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E (Aug 1997). "A novel class of RanGTP binding proteins". J Cell Biol. 138 (1): 65–80. doi:10.1083/jcb.138.1.65. PMC 2139951. PMID 9214382.

[entrez-6] "Entrez Gene: IPO7 importin 7".

IPO7 information

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