A hyperintensity or T2 hyperintensity is an area of high intensity on types of magnetic resonance imaging (MRI) scans of the brain of a human or of another mammal that reflect lesions produced largely by demyelination and axonal loss. These small regions of high intensity are observed on T2 weighted MRI images (typically created using 3D FLAIR) within cerebral white matter (white matter lesions, white matter hyperintensities or WMH)[1][2] or subcortical gray matter (gray matter hyperintensities or GMH). The volume and frequency is strongly associated with increasing age.[2] They are also seen in a number of neurological disorders and psychiatric illnesses. For example, deep white matter hyperintensities are 2.5 to 3 times more likely to occur in bipolar disorder and major depressive disorder than control subjects.[3][4] WMH volume, calculated as a potential diagnostic measure, has been shown to correlate to certain cognitive factors.[5] Hyperintensities appear as "bright signals" (bright areas) on an MRI image and the term "bright signal" is occasionally used as a synonym for a hyperintensity.
Hyperintensities are commonly divided into 3 types depending on the region of the brain where they are found. Deep white matter hyperintensities occur deep within white matter, periventricular white matter hyperintensities occur adjacent to the lateral ventricles and subcortical hyperintensities occur in the basal ganglia.[citation needed]
Hyperintensities are often seen in auto immune diseases that have effects on the brain.[6]
Postmortem studies combined with MRI suggest that hyperintensities are dilated perivascular spaces, or demyelination caused by reduced local blood flow.[7]
^Debette S, Markus HS (2010). "The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis". BMJ. 341: c3666. doi:10.1136/bmj.c3666. PMC 2910261. PMID 20660506.
^ abHabes M, Erus G, Toledo JB, Zhang T, Bryan N, Launer LJ, Rosseel Y, Janowitz D, Doshi J, Van der Auwera S, von Sarnowski B, Hegenscheid K, Hosten N, Homuth G, Völzke H, Schminke U, Hoffmann W, Grabe H, Davatzikos C (2016). "White matter hyperintensities and imaging patterns of brain ageing in the general population". Brain. 139 (Pt 4): 1164–1179. doi:10.1093/brain/aww008. PMC 5006227. PMID 26912649.
^Kempton, Matthew J.; Geddes, JR; Ettinger, U; Williams, SC; Grasby, PM (2008). "Meta-analysis, Database, and Meta-regression of 98 Structural Imaging Studies in Bipolar Disorder". Archives of General Psychiatry. 65 (9): 1017–32. doi:10.1001/archpsyc.65.9.1017. PMID 18762588.
^Videbech, P. (1997). "MRI findings in patients with affective disorder: A meta-analysis". Acta Psychiatrica Scandinavica. 96 (3): 157–68. doi:10.1111/j.1600-0447.1997.tb10146.x. PMID 9296545. S2CID 46065841.
^Brickman, Adam M.; Meier, Irene B.; Korgaonkar, Mayuresh S.; Provenzano, Frank A.; Grieve, Stuart M.; Siedlecki, Karen L.; Wasserman, Ben T.; Williams, Leanne M.; Zimmerman, Molly E. (2012). "Testing the white matter retrogenesis hypothesis of cognitive aging". Neurobiology of Aging. 33 (8): 1699–715. doi:10.1016/j.neurobiolaging.2011.06.001. PMC 3222729. PMID 21783280.
^Theodoridou A, Settas L (2006). "Demyelination in rheumatic diseases". J. Neurol. Neurosurg. Psychiatry. 77 (989): 290–5. doi:10.1136/jnnp.2005.075861. PMC 2077679. PMID 16484634.
^Thomas, Alan J.; Perry, Robert; Barber, Robert; Kalaria, RAJ N.; O'Brien, John T. (2002). "Pathologies and Pathological Mechanisms for White Matter Hyperintensities in Depression". Annals of the New York Academy of Sciences. 977 (1): 333–9. Bibcode:2002NYASA.977..333T. doi:10.1111/j.1749-6632.2002.tb04835.x. PMID 12480770. S2CID 22163039.
A hyperintensity or T2 hyperintensity is an area of high intensity on types of magnetic resonance imaging (MRI) scans of the brain of a human or of another...
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memory loss, seizures, and behavioral anomalies. MRI imaging reveals T2 hyperintensity in the structures of the medial temporal lobes, and in some cases, other...
thickened, darker signal of the junctional zone, one will often see foci of hyperintensity (bright spots) on the T2 weighted scans representing small cystically...
people with bipolar disorder have higher rates of deep white matter hyperintensities. Functional MRI findings suggest that the ventricular prefrontal cortex...
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inversion recovery MRI shows heterogeneous hyperintensity in the same region (arrow) as well as hyperintensity within the gluteus medius and minimus muscles...
outcomes, such as cognitive impairment and depression. White matter hyperintensity are more than often present with vascular dementia, particularly among...
infection and AIDS, characterized by atrophy and ill-defined white matter hyperintensity). Sepsis-associated encephalopathy (this type can occur in the setting...
myelomalacia; magnetic resonance imaging (MRI), or myelography. Diffuse hyperintensity on T2-weighted imaging, and hypointensity on T1-weighted imaging of...
attenuation inversion recovery and T2-weighted sequences. Swelling and hyperintensity may persist over months to years, but in most cases progressive temporomesial...
in a highly mediated, unreal, 'comic' space, Spiegelman captures the hyperintensity of Auschwitz". Belgian publisher La Cinquième Couch produced a book...
shows hyper or iso-intensity on T1-weighted images and heterogenous hyperintensities on T2 weighted images. Pleural schwannoma typically shows fatty degeneration...
website GMH railway station, Elizabeth South, South Australia Gray matter hyperintensity Guam Memorial Hospital Holden, the Australian car making division of...
nuclei and substantia nigra (pars reticulata) against a background of hyperintensity in the tegmentum, as well as hypointensity of the superior colliculi...
nonspecific white matter lesions, or 2) optic nerve MRI showing T2-hyperintensity, or T1 enhancing lesion, greater than 1/2 optic nerve length or involving...
internal carotid artery within the cavernous sinus, and an obvious signal hyperintensity within thrombosed vascular sinuses on all pulse sequences. Cerebral...
silico analysis. MRIs show hypointensities on T1-weighted images and hyperintensities on T2-weighted images, usually multiple confluent white matter lesions...
tumors which share many similar features to ganglioglioma, including T2 hyperintensity, enhancement, tumoral cysts, and cord edema. Poorly defined margins...
traction responsive myelopathy are evident on MRI. The spinal-cord hyperintensity seen at the C5-C6 is suggestive of chronic lesion and most likely responsible...
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, 2004). In addition, the brains of METH abusers show evidence of hyperintensities in white matter (Bae et al., 2006; Ernst et al., 2000), decreases in...
superficial siderosis). Other MRI indicators of CAA include white matter hyperintensities and cortical thinning. The aim in cerebral amyloid angiopathy is to...