The Human Proteome Folding Project (HPF) is a collaborative effort between New York University (Bonneau Lab), the Institute for Systems Biology (ISB) and the University of Washington (Baker Lab), using the Rosetta software developed by the Rosetta Commons. The project is managed by the Bonneau lab.
HPF Phase 1 applied Rosetta v4.2x software on the human genome and 89 others, starting in November 2004. Phase 1 ended in July 2006. HPF Phase 2 (HPF2) applies the Rosetta v4.8x software in higher resolution, "full atom refinement" mode, concentrating on cancer biomarkers (proteins found at dramatically increased levels in cancer tissues), human secreted proteins and malaria.
Phase 1 ran on two volunteer computing grids: on United Devices' grid.org, and on the World Community Grid, an IBM philanthropic initiative. Phase 2 of the project ran exclusively on the World Community Grid; it terminated in 2013 after more than 9 years of IBM involvement.[1]
The Institute for Systems Biology will use the results of the computations within its larger research efforts.
WCG screensaver, Human Proteome Folding Project Phase2, running under UD client software
^World Community Grid Post - HPF2 Update, June 2013, archived from the original on 4 March 2016, retrieved 14 July 2015
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The HumanProteomeFoldingProject (HPF) is a collaborative effort between New York University (Bonneau Lab), the Institute for Systems Biology (ISB) and...
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the humanproteome reaches a major milestone:> 90% of predicted human proteins now credibly detected, according to the HUPO humanproteomeproject". Journal...
Sunderland, MA: Sinauer Associates. ISBN 9780878932368. "The humanproteome in brain – The Human Protein Atlas". www.proteinatlas.org. Archived from the original...
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co-translational protein folding introduces several spatial and temporal constraints on the nascent polypeptide chain in its folding trajectory. Because mRNA...
Livingstone. pp. 295–299. ISBN 978-0-8089-2306-0. "The humanproteome in small intestine - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2017-09-26...
original on 23 August 2018. Retrieved 31 July 2016. "The humanproteome in heart – The Human Protein Atlas". www.proteinatlas.org. Archived from the original...
L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8...
(2000). "The nature and significance of protein folding". In Pain RH (ed.). Mechanisms of Protein Folding. Oxford, Oxfordshire: Oxford University Press...
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molecule drug discovery by analyzing protein-small molecule interactions on a proteome-wide scale. A major goal of chemoproteomics is to characterize the interactome...
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