Histatins are histidine-rich (cationic) antimicrobial proteins found in saliva.[1] Histatin's involvement in antimicrobial activities makes histatin part of the innate immune system.[2]
Histatin was first discovered (isolated) in 1988, with functions that's responsible in keeping homeostasis inside the oral cavity, helping in the formation of pellicles, and assist in bonding of metal ions.[3]
^Histatins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
^Qin Y, Zhang L, Xu Z, Zhang J, Jiang YY, Cao Y, Yan T (July 2016). "Innate immune cell response upon Candida albicans infection". Virulence. 7 (5): 512–26. doi:10.1080/21505594.2016.1138201. PMC 5026795. PMID 27078171.
^Khurshid Z, Najeeb S, Mali M, Moin SF, Raza SQ, Zohaib S, Sefat F, Zafar MS (January 2017). "Histatin peptides: Pharmacological functions and their applications in dentistry". Saudi Pharmaceutical Journal. 25 (1): 25–31. doi:10.1016/j.jsps.2016.04.027. PMC 5310145. PMID 28223859.
Histatins are histidine-rich (cationic) antimicrobial proteins found in saliva. Histatin's involvement in antimicrobial activities makes histatin part...
Histatin-1 is a protein that in humans is encoded by the HTN1 gene. ENSG00000126550 GRCh38: Ensembl release 89: ENSG00000283046, ENSG00000126550 – Ensembl...
Histatin 3, also known as HTN3, is a protein which in humans is encoded by the HTN3 gene. The primary protein encoded by HTN3 is histatin 3. Histatins...
which have also been shown to have another function in the secretion of histatins which offer an early defense (outside of the immune system) against microbes...
radicals. Additionally Franz studies copper-binding peptides such as histatin. Histatin binds to copper in vitro, but it is not clear how they interact or...
enzymes (for more on that topic, see plant defense against herbivory). Histatins, another type of salivary proteins, also precipitate tannins from solution...
of EGF and NGF in humans are much lower than those in rats. In humans, histatins may play a larger role. As well as being growth factors, IGF-I and TGF-α...
particular interest to the scientific community (e.g. the divalent bacitracin, histatin and Fe/Cu-bleomycin). At the same time there is an increasing attention...
recombinant histatin and statherin strains is more prevalent as they are smaller and simpler in structure. Therefore, a range of histatin and statherin...
which in turn breaks down the bacterium. Antimicrobial peptides such as histatins inhibit the growth of Candida albicans and Streptococcus mutans. Salivary...
Saitoh E, Azen EA (1990). "Tissue distribution of RNAs for cystatins, histatins, statherin, and proline-rich salivary proteins in humans and macaques"...
alterations and autofluorescent conversion of Candida albicans induced by histatins". Microscopy Research and Technique. 66 (5): 219–28. doi:10.1002/jemt...
bioactive peptides of animal origin, such as human antimicrobial peptide histatin, conotoxin from cone snail and insect antimicrobial peptide thanatin. The...
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