Haptocorrin (HC) also known as transcobalamin-1 (TC-1) or cobalophilin is a transcobalamin protein that in humans is encoded by the TCN1 gene.[3] One essential function of haptocorrin is protection of the acid-sensitive vitamin B12 while it moves through the stomach. A second function is serum HC binding of the great majority of circulating vitamin B12, rendering it unavailable for take-up by cells. This is conjectured to be a circulating storage function.
^ abcGRCh38: Ensembl release 89: ENSG00000134827 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: transcobalamin I (vitamin B12 binding protein".
Haptocorrin (HC) also known as transcobalamin-1 (TC-1) or cobalophilin is a transcobalamin protein that in humans is encoded by the TCN1 gene. One essential...
the gastric intrinsic factor protein is encoded by the CBLIF gene. Haptocorrin (transcobalamin I) is another glycoprotein secreted by the salivary glands...
proteins which bind cobalamin (B12). Transcobalamin I (TC-1), also known as haptocorrin (HC), R-factor, and R-protein is encoded in the human by the TCN1 gene...
vitamin B 12 requires successively three different protein molecules: haptocorrin, intrinsic factor and transcobalamin II. Methylcobalamin Hydroxocobalamin...
complexes. After the B12-haptocorrin complexes pass from the stomach via the pylorus to the duodenum, pancreatic proteases cleave haptocorrin from the B12 molecules...
importantly that of parotitis. Saliva also contains a glycoprotein called haptocorrin which is a binding protein to vitamin B12. It binds with the vitamin...
foul odor. Opiorphin, a pain-killing substance found in human saliva Haptocorrin, a protein which binds to vitamin B12 to protect it against degradation...
may be carried out to measure cerebrospinal fluid B12 levels. Serum haptocorrin binds 80-90% of circulating B12, rendering it unavailable for cellular...
deficiency, such as folate deficiency, pregnancy, oral contraceptive use, haptocorrin deficiency, and myeloma. High serum levels may caused by supplementing...
functional secretion of salivary haptocorrin, functional secretion of gastric intrinsic factor, functional cleavage of the haptocorrin via pancreatic protease...
transcobalamins. Most of the time, 80–94% of vitamin B12 in the blood binds to haptocorrin, while only 6–20% is binds to transcobalamin ll. Only transcobalamin...
Cobalamins circulate bound to serum proteins called transcobalamins (TC) and haptocorrins. Hydroxocobalamin has a higher affinity to the TC II transport protein...
kinetics and ligand protection for intrinsic factor, transcobalamin, and haptocorrin". J. Biol. Chem. 277 (12): 9989–96. doi:10.1074/jbc.M111399200. PMID 11788601...
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