Cubam, is the term used to refer to a multi-ligand receptor located in the terminal ileum, specializing in absorption of vitamin B12. Cubam is essentially composed of amnionless (AMN), and cubilin.[1][2] Cubilin is essential as a cell receptor recognizing the "vitamin B12-intrinsic factor" complex, whereas amnionless is more involved in the receptor mediated endocytosis of the complex.
^Pedersen, Gitte Albinus; Chakraborty, Souvik; Stinhauser, Amie L.; Traub, Linton M.; Madsen, Mette (2010). "AMN directs endocytosis of the intrinsic factor-vitamin B(12) receptor cubam by engaging ARH or Dab2". Traffic. 11 (5): 706–20. doi:10.1111/j.1600-0854.2010.01042.x. PMC 2964065. PMID 20088845.
^Quadros, Edward V. (2010). "Advances in the understanding of cobalamin assimilation and metabolism". British Journal of Haematology. 148 (2): 195–204. doi:10.1111/j.1365-2141.2009.07937.x. PMC 2809139. PMID 19832808.
Cubam, is the term used to refer to a multi-ligand receptor located in the terminal ileum, specializing in absorption of vitamin B12. Cubam is essentially...
vitamin to receptor proteins cubilin and amnionless, which together form the cubam receptor in the distal ileum. The receptor is specific to the IF-B12 complex...
This pathway is mediated by LRP2 and CUBAM, where Dab2 binds to the cytoplasmic tails of both LRP2 and CUBAM to initiate clathrin-coated endocytosis...
intrinsic factor-B12-complex is absorbed by enterocytes in the ileum's cubam receptors. PA is characterised by B12 deficiency caused by the absence of...
recessive megaloblastic anemia. A complex of amnionless and cubilin forms the cubam receptor. Cubilin is a potential diagnostic and prognostic cancer biomarker...
B12 characteristic of the disease is due to genetic malfunction of the Cubam receptor located in the terminal ileum. Imerslund was born at Vang in Hedmark...
encoded by the AMN gene. A complex of amnionless and cubilin forms the cubam receptor. The protein encoded by this gene is a type I transmembrane protein...
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