positive regulation of transcription regulatory region DNA binding
peripheral nervous system neuron development
roof of mouth development
apoptotic process involved in heart morphogenesis
noradrenergic neuron differentiation
cell differentiation
mesenchymal cell proliferation
determination of heart left/right asymmetry
regulation of transcription, DNA-templated
sympathetic nervous system development
tongue development
neural crest cell development
cell proliferation involved in outflow tract morphogenesis
adult heart development
cardiac right ventricle formation
thymus development
mesenchyme development
cardiac neural crest cell migration involved in outflow tract morphogenesis
negative regulation of DNA binding
coronary artery morphogenesis
embryonic digit morphogenesis
positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process
visceral serous pericardium development
heart morphogenesis
negative regulation of apoptotic process
in utero embryonic development
negative regulation of DNA-binding transcription factor activity
negative regulation of osteoblast differentiation
transcription, DNA-templated
cardiac neural crest cell development involved in outflow tract morphogenesis
positive regulation of transcription, DNA-templated
heart looping
odontogenesis of dentin-containing tooth
positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis
multicellular organism development
negative regulation of cardiac muscle cell apoptotic process
heart development
regulation of secondary heart field cardioblast proliferation
angiogenesis
cartilage morphogenesis
positive regulation of transcription by RNA polymerase II
suckling behavior
regulation of tissue remodeling
negative regulation of gene expression
positive regulation of ERK1 and ERK2 cascade
positive regulation of p38MAPK cascade
positive regulation of cardiac muscle hypertrophy
positive regulation of gene expression
transcription by RNA polymerase II
primary palate development
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9464
15111
Ensembl
ENSG00000164107
ENSMUSG00000038193
UniProt
P61296
Q61039
RefSeq (mRNA)
NM_021973
NM_010402
RefSeq (protein)
NP_068808
NP_034532
Location (UCSC)
Chr 4: 173.52 – 173.53 Mb
Chr 8: 57.77 – 57.78 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Heart- and neural crest derivatives-expressed protein 2 is a protein that in humans is encoded by the HAND2 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000164107 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000038193 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Russell MW, Kemp P, Wang L, Brody LC, Izumo S (December 1998). "Molecular cloning of the human HAND2 gene". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (3): 393–9. doi:10.1016/S0167-4781(98)00237-1. PMID 9878849.
^"Entrez Gene: HAND2 heart and neural crest derivatives expressed 2".
derivatives-expressed protein 2 is a protein that in humans is encoded by the HAND2 gene. The protein encoded by this gene belongs to the basic helix-loop-helix...
50013-7, ISBN 978-0-8016-7522-5, retrieved 2020-12-12 Anatomy image: skel/hand2 at Human Anatomy Lecture (Biology 129), Pennsylvania State University Portal:...
trunk and the proximal segment of the arch of aorta, respectively. Genes HAND2 (dHAND) and HAND1 (eHAND) are expressed during the development of the aortic...
other factors that are needed for ZPA maintenance and function including Hand2 and Hoxb-8. Retinoic acid, an important signaling molecule needed throughout...
GATA4 has been shown to interact with NKX2-5, TBX5, Serum response factor HAND2, and HDAC2. GATA4 has also been shown to interact with Erbb3, FOG-1, and...
also depends on heart specific proteins activated by Nkx2.5 such as Hand1, Hand2, and Xin. Heart chamber formation: The cell fates of the heart chambers...
ventricular chambers, cardiac neural crest, endocardium (HAND2 only) and epicardium (HAND2 only). HAND1 is expressed with myocardium of the primary heart...