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HAMP
Identifiers
Symbol
HAMP
Pfam
PF00672
InterPro
IPR003660
SCOP2
2asx / SCOPe / SUPFAM
OPM protein
5iji
CDD
cd06225
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
In molecular biology, the HAMP domain (present in Histidine kinases, Adenylate cyclases, Methyl accepting proteins and Phosphatases)[1] is an approximately 50-amino acid alpha-helical region that forms a dimeric, four-helical coiled coil.[2] It is found in bacterial sensor and chemotaxis proteins and in eukaryotic histidine kinases. The bacterial proteins are usually integral membrane proteins and part of a two-component signal transduction pathway. One or several copies of the HAMP domain can be found in association with other domains, such as the histidine kinase domain, the bacterial chemotaxis sensory transducer domain, the PAS repeat, the EAL domain, the GGDEF domain, the protein phosphatase 2C-like domain, the guanylate cyclase domain, or the response regulatory domain.[3] In its most common setting, the HAMP domain transmits conformational changes in periplasmic ligand-binding domains to cytoplasmic signalling kinase and methyl-acceptor domains and thus regulates the phosphorylation or methylation activity of homodimeric receptors.
^Aravind L, Ponting CP (July 1999). "The cytoplasmic helical linker domain of receptor histidine kinase and methyl-accepting proteins is common to many prokaryotic signalling proteins". FEMS Microbiology Letters. 176 (1): 111–6. doi:10.1016/s0378-1097(99)00197-4. PMID 10418137.
^Hulko M, Berndt F, Gruber M, Linder JU, Truffault V, Schultz A, Martin J, Schultz JE, Lupas AN, Coles M (September 2006). "The HAMP domain structure implies helix rotation in transmembrane signaling". Cell. 126 (5): 929–40. doi:10.1016/j.cell.2006.06.058. PMID 16959572. S2CID 18396561.
^Dunin-Horkawicz S, Lupas AN (April 2010). "Comprehensive analysis of HAMP domains: implications for transmembrane signal transduction". Journal of Molecular Biology. 397 (5): 1156–74. doi:10.1016/j.jmb.2010.02.031. PMID 20184894.
In molecular biology, the HAMPdomain (present in Histidine kinases, Adenylate cyclases, Methyl accepting proteins and Phosphatases) is an approximately...
have identified three conserved signature indels (CSIs) in the proteins HAMPdomain-containing protein, phospho-N-acetylmuramoyl-pentapeptide-transferase...
Schultz, Joachim E. (2014). "Biochemical characterization of the tandem HAMPdomain from Natronomonas pharaonis as an intraprotein signal transducer". FEBS...
Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the circulation in mammals. During...
second liens when a homeowner receives a first lien modification through HAMP. Home Affordable Foreclosure Alternatives Program (HAFA), helps homeowners...
HtrII consists of two transmembrane helices, two HAMP-domains and methyl-accepting signalling domain. In case of Halobacterium salinarum HtrII also comprises...
Theodor Capidan referenced in (Hamp 1963, p. 104) Weigand, as referenced in (Hamp 1963, p. 104) Baric, as referenced in (Hamp 1963, p. 104) 1994 Gottfried...
otherworld terms". Celtic Language, Celtic Culture: a Festschrift for Eric P. Hamp, ed. Ann T. E. Matonis and Daniel F. Mela, pp. 57–84. Van Nuys, Ca.: Ford...
Acts 8:39, 2 Corinthians 12:2–4, and Revelation 12:5. Linguist, Dr. Douglas Hamp, notes that Greek scholar Spiros Zodhiates lists harpagēsometha as the first-person...
derived from the Welsh mab, which means "son, boy, young person". Eric P. Hamp, of the earlier school traditions in mythology, found a suggestive connection...
refinance their mortgages. Unlike the Home Affordable Modification Program (HAMP), which assists homeowners who are in danger of foreclosure, this program...
assyrianlanguages.org. Retrieved 2020-07-31. Köstenberger 2009, p. 350. Hamp 2005, p. 4. Buth & Pierce 2014, pp. 107–109. Kautzsch, Emil Friedrich (1884)...
Armenian to be most closely related to Greek and Ancient Macedonian. Eric P. Hamp placed Armenian in the "Pontic Indo-European" (also called Graeco-Armenian...
transmitting HIV contrary to the HIV/AIDS Management and Prevention Act (HAMP) Act 2003 is sometimes used to detain sex workers, but there is no evidence...
S.; Ament, F.; Hirsch, L.; Hagen, M.; Peters, G.; Stevens, B. (2014). "HAMP: the microwave package on the High Altitude and LOng range research aircraft...
given by the Greeks, meant "eel-men". In Greek mythology. According to E. Hamp, a connection with Albanian ngjalë makes it possible that the name Enchele...
Architecture and pilgrimage, 1000–1500: southern Europe and beyond. Aldershot, Hamps.: Ashgate Publishing. pp. 73–86. ISBN 9781472410832. St. James Church 1963...
Medicine. 22 (2): 135–150. doi:10.1016/j.molmed.2015.12.004. PMID 26787500. Hamp I, O'Neill TJ, Plettenburg O, Krappmann D (2021). "A patent review of MALT1...
as monstrous. In book 3 of his Corrupting the Image series, Dr. Douglas Hamp goes so far as to suggest that the Beast of John's Apocalypse is himself...
plant or microbe/pathogen-associated-molecular-patterns (MAMPs, PAMPs, or HAMPs) if from the parasite, engage pattern-recognition receptors (PRRs) triggering...
hemochromatosis patients. A small number of patients have mutations in the hepcidin (HAMP) gene. The gene was positionally cloned. Hemojuvelin is highly expressed...
Matzinger 2012, pp. 643–644. Kortlandt 2003, p. 86. Vermeer 1996, p. 126, 128. Hamp 1980, p. 60. Demiraj 2006, p. 78. Malcolm 1998, p. 33. Sala 2005, p. 29....
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