Glycogenin is an enzyme involved in converting glucose to glycogen. It acts as a primer, by polymerizing the first few glucose molecules, after which other enzymes take over. It is a homodimer of 37-kDa subunits and is classified as a glycosyltransferase.
Thus, the two substrates of this enzyme are UDP-alpha-D-glucose and glycogenin, whereas its two products are UDP and alpha-D-glucosylglycogenin.[2][3]
^PDB: 1LL3; Gibbons BJ, Roach PJ, Hurley TD (May 2002). "Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin". J. Mol. Biol. 319 (2): 463–77. doi:10.1016/S0022-2836(02)00305-4. PMID 12051921.
^Barengo R, Krisman CR (May 1978). "Initiation of glycogen biosynthesis in Escherichia coli. Studies of the properties of the enzymes involved". Biochimica et Biophysica Acta (BBA) - General Subjects. 540 (2): 190–6. doi:10.1016/0304-4165(78)90131-9. PMID 418819.
^Butler NA, Lee EY, Whelan WJ (May 1977). "A protein-bound glycogen component of rat liver". Carbohydrate Research. 55: 73–82. doi:10.1016/s0008-6215(00)84444-4. PMID 861979.
Glycogenin is an enzyme involved in converting glucose to glycogen. It acts as a primer, by polymerizing the first few glucose molecules, after which other...
centered on a glycogenin protein, with three kinds of glucose chains: A, B, and C. There is only one C-chain, attached to the glycogenin. This C-chain...
glycogenin is needed to create initial short glycogen chains, which are then lengthened and branched by the other enzymes of glycogenesis. Glycogenin...
Glycogen is a highly branched structure, consisting of the core protein Glycogenin, surrounded by branches of glucose units, linked together. The branching...
however, that the unique reducing end is usually covalently linked to glycogenin and will therefore not be reducing). Each branch ends in a nonreducing...
Oldfors A (2014) A new muscle glycogen storage disease associated with glycogenin-1 deficiency. Ann Neurol 76(6):891-898 Moslemi, Ali-Reza; Lindberg, Christopher;...
hydrolysis. Schematic 2-D cross-sectional view of glycogen. A core protein of glycogenin is surrounded by branches of glucose units. The entire globular granule...
FILIP1L: encoding protein Filamin A interacting protein 1 like GYG1: Glycogenin-1 HACD2 encoding protein 3-hydroxyacyl-CoA dehydratase 2 HGD: homogentisate...
requires an oligosaccharide primer as a glucose acceptor, it relies on glycogenin to initiate de novo glycogen synthesis. In a recent study of transgenic...
binding 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) Cellular component cytosol extracellular...
action of the enzyme UDP-glucose pyrophosphorylase (UGP). The enzyme glycogenin (GYG) is needed to create initial short glycogen chains, which are lengthened...
glycogen synthesis. The initiation of synthesis of glycogen requires glycogenin, found in glycosomes, a protein primer. Glycogen synthase as mentioned...
who worked on the structure of glycogen, and discovered the protein glycogenin at its core. He was very active in the creation of international organizations...
starch and glycogen. He discovered that glycogen contained the protein glycogenin. He was elected as a Fellow of the Royal Society in 1992. He died on 5...
work provided evidence for the existence of a protein core, now known as glycogenin, within glycogen. He was deputy Dean of Science from 1982 to 1985 at the...
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