Migraine is often hereditary. It is estimated that 60% of migraine cases are caused by genetics.[1] The role of natural selection in the development of migraines is not known. Fitness-impairing disorders, including migraines, tend to disappear as a result of natural selection, and their frequency decreases to near the rate of spontaneous mutation.[unreliable medical source?][2] However, it is estimated that migraines affect 15-20% of the population and is increasing.[1] This could suggest that a central nervous system (CNS) susceptible to severe, intermittent headache has been linked to an important survival or reproductive advantage. Five possible evolutionary explanations exist: i) migraine as a defence mechanism, ii) migraine as a result of conflicts with other organisms, iii) migraine as a result of novel environmental factors, iv) migraine as a compromise between genetic harms and benefits, and v) headache as a design constraint.[3] These considerations allow the treatment and prevention of migraine to be approached from an evolutionary medicine perspective.[medical citation needed]
^ abBron, Charlene; Sutherland, Heidi G.; Griffiths, Lyn R. (2021-04-22). "Exploring the Hereditary Nature of Migraine". Neuropsychiatric Disease and Treatment. 17: 1183–1194. doi:10.2147/NDT.S282562. PMC 8075356. PMID 33911866.
^[unreliable medical source?]Nesse, RM; Williams, GC (November 1998). "Evolution and the origins of disease". Scientific American. 279 (5): 86–93. Bibcode:1998SciAm.279e..86N. doi:10.1038/scientificamerican1198-86. PMID 9796548. Erratum in Sci Am 1999 Mar;280(3):14.
^Loder, E (1 October 2002). "What is the evolutionary advantage of migraine?". Cephalalgia (Review). 22 (8): 624–632. doi:10.1046/j.1468-2982.2002.00437.x. PMID 12383059. S2CID 1781214.
and 25 Related for: Genetics of migraine information
Migraine is often hereditary. It is estimated that 60% ofmigraine cases are caused by genetics. The role of natural selection in the development of migraines...
Migraine (UK: /ˈmiːɡreɪn/, US: /ˈmaɪ-/) is a genetically influenced complex neurological disorder characterized by episodes of moderate-to-severe headache...
The terms "retinal migraine" and "ocular migraine" are often confused with "visual migraine", which is a far-more-common symptom of vision loss, resulting...
Abdominal migraine (AM) is a functional disorder that usually manifests in childhood and adolescence, without a clear pathologic mechanism or biochemical...
Hemiplegic migraine is a type ofmigraine headache characterized by motor weakness affecting only one side of the body, accompanied by aura. There is often...
edition): Genetics in Migraine". Archived from the original on 19 July 2009. Retrieved 24 June 2015. Lee, Ann (11 July 2022). "'It starts as a line of light...
start with attacks ofmigraine with aura or subcortical transient ischemic attacks or strokes, or mood disorders between 35 and 55 years of age. The disease...
Familial hemiplegic migraine (FHM) is an autosomal dominant type of hemiplegic migraine that typically includes weakness of half the body which can last...
or blurred vision Dysphagia, or the sensation of being choked Dyspnea Fatigue Lhermitte's sign Migraine headaches Nausea Neck, shoulder, and jaw pain...
Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California. One of the world's largest...
type ofmigraine. Sporadic hemiplegic migraine (SHM) has clinical symptoms identical to familial hemiplegic migraine (FHM) and distinct from migraine with...
received his PhD in human genetics from Leiden University with a dissertation titled "The molecular basis of familial hemiplegic migraine". "Roel Ophoff". Catalogus...
or sweating, typically appearing on the same side of the head as the pain. Similar to a migraine, sensitivity to light (photophobia) or noise (phonophobia)...
a variety of pain syndromes such as neuropathic pain, fibromyalgia, migraine and tension headaches. Due to the frequency and prominence of side effects...
by several groups in the early 1980s as a natural extension of classical population genetics theory and models,[1][2][3][4] but can be primarily attributed...
lighting/migraine, allowing a person to "ride out the migraine" in a dark or dim room. A paper by Stringham and Hammond, published in the Journal of Food...
abnormality of the neuroendocrine system that affects 2% of children." This disorder is thought to be closely related to migraines and family history of migraines...
association analysis identifies susceptibility loci for migraine without aura". Nature Genetics. 44 (7): 777–782. doi:10.1038/ng.2307. PMC 3773912. PMID 22683712...
Previously AHC was thought to be a form of complicated migraine because of strong family histories ofmigraine reported in AHC cases. AHC has also been...
treat epilepsy and bipolar disorder and prevent migraine headaches. They are useful for the prevention of seizures in those with absence seizures, partial...
the treatment of psoriasis, has been known to cause hyperosmia, and may be more likely to do so in patients with a history ofmigraines. However, this...
disease. Children with ADHD have a higher risk for migraine headaches, but have no increased risk of tension-type headaches. In addition, children with...
echocardiography, shunting of blood may not be noted except when the patient coughs.[citation needed] PFO is linked to stroke, sleep apnea, migraine with aura, cluster...
population. This includes increased rates of metabolic syndrome (present in 37% of people with bipolar disorder), migraine headaches (35%), obesity (21%) and...
prevalence ofmigraine headaches. The cause of congenital astigmatism is unclear; however, it is believed to be partly related to genetic factors. Genetics, based...
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