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American biotechnology company
GeneDx
Company type
Public
Traded as
Nasdaq: WGS
Industry
Biotechnology, genome testing
Founded
2000; 24 years ago (2000)
Founder
Sherri Bale, John Compton
Headquarters
Gaithersburg, Maryland
Key people
Katherine Stueland (CEO)
Jason Ryan (Executive Chair of the Board)
Products
Exome/genome sequencing
Website
www.genedx.com
GeneDx is a genetic testing company that was founded in 2000 by two scientists from the National Institutes of Health (NIH), Sherri Bale and John Compton.[1][2][3][4][5][6][7] They started the company to provide clinical diagnostic services for patients and families with rare and ultra-rare disorders, for which no such commercial testing was available at the time. The company started in the Technology Development Center, a biotech incubator supported by the state of Maryland and Montgomery County, MD. In 2006, BioReference Laboratories acquired GeneDx.[8] Since then, GeneDx has operated as a subsidiary of this parent company under the leadership of Bale (retired in 2016) and Compton (retired in 2013).[9] In October 2016, Benjamin D. Solomon was appointed as managing director.[10]
GeneDx works with the medical, scientific, and patient advocacy communities to continuously develop new genetic tests not currently available at other clinical laboratories. GeneDx currently offers tests for hundreds of rare diseases, as well as panels of genes and whole exome sequencing (20,000 gene) Mendelian disorders using massively-parallel DNA sequencing and deletion/duplication analysis of the associated gene(s). GeneDx also performs oligonucleotide-based microarray testing for the detection of chromosomal abnormalities (genomic losses or gains) in individuals with chromosomal anomalies. GeneDx provides testing for autism spectrum disorders, various forms of cardiomyopathy, inherited eye, skin, muscle, hearing, metabolic, neurologic, and mitochondrial disease.[citation needed]
GeneDx settled a patent dispute with Myriad Genetics in February 2015 after GeneDx launched a BRCA mutation breast cancer genetic screening test following the US Supreme Court decision in Association for Molecular Pathology v. Myriad Genetics, Inc. that concluded isolated gene sequences were patent ineligible.[11]
^"GeneDX Founders Find Market for Diagnostic Tests". The Washington Post. Retrieved 2023-05-27.
^"Maryland's Incubator Update" (PDF). Maryland State Archives. Retrieved 2023-05-27.
^"About Us". GeneDx. Retrieved 2023-05-27.
^"Rebranded GeneDx Bets Future on Whole-Exome, Whole-Genome Sequencing in Pediatric Rare Disease". GenomeWeb. Retrieved 2023-05-27.
^"Montgomery College (Pinkney Innovation Complex for Science and Technology Foundation Officers)". Montgomery College. Retrieved 2023-05-27.
GeneDx is a genetic testing company that was founded in 2000 by two scientists from the National Institutes of Health (NIH), Sherri Bale and John Compton...
BioReference, a biotech company and led several biotech companies including GeneDx and Genosity. Raised in Califon, New Jersey as "the one Jew in a very, very...
Synthetase Deficiency / Multiple Carboxylase Deficiency". HLCS Gene Sequencing. GeneDx. Archived from the original on 21 September 2019. Retrieved 28...
and life science companies including AstraZeneca, BioNTech, GeneDx, Qiagen, American Gene Technologies, and GlaxoSmithKline. A defining feature of the...
Bioinformatics UMUC, University System of Maryland UMUC Master of Biotechnology GeneDx Business Analytics Columbia University Columbia University MS in Management...
Argentine-American computational systems biologist. He was the CSO of Sema4 and then of GeneDx until December 2023. Between 1998 and 2021 he was a researcher and executive...
genetic testing company GeneDx has uploaded genes from its database with likely pathogenic variants, leading to dozens of matches. GeneMatcher has helped geneticists...
The light novel, manga, and anime series High School DxD features a diverse cast of characters. The visuals of the characters were designed by Miyama-Zero...
as RT-PCR to measure the expression of the 12-gene panel. Prior to selecting genes for the Oncotype DX Colon Cancer Assay, feasibility studies were conducted...
The IUCN Red List of Threatened Species 2019: e.T77727073A77727085. https://dx.doi.org/10.2305/IUCN.UK.2019-2.RLTS.T77727073A77727085.en. Accessed on 28...
especially in relation to approaches making use of new cell therapy or gene therapy developments. Its origins lie with the long-existing company PerkinElmer...
Action Everywhere (DxE) is an international grassroots network of animal rights activists founded in 2013 in the San Francisco Bay Area. DxE uses disruptive...
protein in a biological cell. These peptides share a core sequence motif of DxExNPGP, and are found in a wide range of viral families. 2A peptides can be...
( x ) d x ≈ ∑ i = 1 n w i f ( x i ) , {\displaystyle \int _{-1}^{1}f(x)\,dx\approx \sum _{i=1}^{n}w_{i}f(x_{i}),} which is exact for polynomials of degree...
decisions". Oncotype DX assesses 16 cancer-related genes and 5 normal comparator reference genes, and is therefore sometimes known as the 21-gene assay. It was...
Stories and Green Eggs and Pam Productions, Inc. Ended The Offer Paramount+ DxD Films, The White Mountain Company, and Black Mass Productions Miniseries...
flowers of Icetor boiled in spring water. DX The Lost World by Michael Crichton An unknown prion dubbed "DX" by scientists on Isla Sorna. It is similar...
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