transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Cellular component
integral component of membrane
GABA-A receptor complex
postsynaptic membrane
membrane
plasma membrane
synapse
integral component of plasma membrane
chloride channel complex
cell junction
neuron projection
GABA-ergic synapse
Biological process
gamma-aminobutyric acid signaling pathway
chloride transmembrane transport
ion transport
chloride transport
signal transduction
visual perception
chemical synaptic transmission
ion transmembrane transport
regulation of membrane potential
nervous system process
regulation of postsynaptic membrane potential
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2570
14409
Ensembl
ENSG00000111886
ENSMUSG00000023267
UniProt
P28476
P56476
RefSeq (mRNA)
NM_002043
NM_008076
RefSeq (protein)
NP_002034
NP_032102
Location (UCSC)
Chr 6: 89.25 – 89.32 Mb
Chr 4: 33.06 – 33.1 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Gamma-aminobutyric acid receptor subunit rho-2 is a protein that in humans is encoded by the GABRR2 gene.[5][6]
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR2 is a member of the rho subunit family.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000111886 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000023267 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR (May 1992). "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4". Genomics. 12 (4): 801–806. doi:10.1016/0888-7543(92)90312-G. PMID 1315307.
acid receptor subunit rho-2 is a protein that in humans is encoded by the GABRR2 gene. GABA is the major inhibitory neurotransmitter in the mammalian brain...
(GABRE), a π (GABRP), and a θ (GABRQ) There are three ρ units (GABRR1, GABRR2, GABRR3); however, these do not coassemble with the classical GABAA units...
receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4"...
(June 2011). "Potential role of GABAA receptor subunit; GABRA6, GABRB2 and GABRR2 gene polymorphisms in epilepsy susceptibility and pharmacotherapy in North...