ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Cellular component
integral component of membrane
GABA-A receptor complex
postsynaptic membrane
membrane
plasma membrane
synapse
integral component of plasma membrane
chloride channel complex
cell junction
neuron projection
glutamatergic synapse
GABA-ergic synapse
Biological process
gamma-aminobutyric acid signaling pathway
chloride transmembrane transport
ion transport
chloride transport
chemical synaptic transmission
ion transmembrane transport
signal transduction
regulation of membrane potential
nervous system process
regulation of postsynaptic membrane potential
regulation of presynaptic membrane potential
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2569
14408
Ensembl
ENSG00000146276
ENSMUSG00000028280
UniProt
P24046
P56475
RefSeq (mRNA)
NM_001256703 NM_001256704 NM_001267582 NM_002042
NM_008075
RefSeq (protein)
NP_001243632 NP_001243633 NP_001254511 NP_002033
NP_032101
Location (UCSC)
Chr 6: 89.18 – 89.23 Mb
Chr 4: 33.13 – 33.16 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Gamma-aminobutyric acid receptor subunit rho-1 is a protein that in humans is encoded by the GABRR1 gene.[5][6][7]
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000146276 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028280 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cutting GR, Lu L, O'Hara BF, Kasch LM, Montrose-Rafizadeh C, Donovan DM, Shimada S, Antonarakis SE, Guggino WB, Uhl GR, et al. (May 1991). "Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina". Proc Natl Acad Sci U S A. 88 (7): 2673–2677. Bibcode:1991PNAS...88.2673C. doi:10.1073/pnas.88.7.2673. PMC 51300. PMID 1849271.
^Cutting GR, Curristin S, Zoghbi H, O'Hara B, Seldin MF, Uhl GR (May 1992). "Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4". Genomics. 12 (4): 801–806. doi:10.1016/0888-7543(92)90312-G. PMID 1315307.
acid receptor subunit rho-1 is a protein that in humans is encoded by the GABRR1 gene. GABA is the major inhibitory neurotransmitter in the mammalian brain...
(GABRD), an ε (GABRE), a π (GABRP), and a θ (GABRQ) There are three ρ units (GABRR1, GABRR2, GABRR3); however, these do not coassemble with the classical GABAA...
radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3". Biochim. Biophys. Acta. 1447 (2–3): 307–312. doi:10...
rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4". Genomics. 12 (4):...
Global Information
