Proprotein convertases (PPCs) are a family of proteins that activate other proteins. Many proteins are inactive when they are first synthesized, because they contain chains of amino acids that block their activity. Proprotein convertases remove those chains and activate the protein. The prototypical proprotein convertase is furin.[1] Proprotein convertases have medical significance, because they are involved in many important biological processes, such as cholesterol synthesis.[2] Compounds called proprotein convertase inhibitors can block their action, and block the target proteins from becoming active. Many proprotein convertases, especially furin and PACE4, are involved in pathological processes such as viral infection, inflammation, hypercholesterolemia, and cancer, and have been postulated as therapeutic targets for some of these diseases.[3]
^Andrew W. Artenstein; Steven M. Opal (December 29, 2011). "Proprotein Convertases in Health and Disease". N Engl J Med. 365 (26): 2507–2518. doi:10.1056/NEJMra1106700. PMID 22204726.
^New Drugs for Lipids Set Off Race, By ANDREW POLLACK, New York Times, November 5, 2012
^The Role of Proprotein Convertases in Animal Models of Skin Carcinogenesis, by Daniel Bassi, Morgan & Claypool Publishers, 2012, DOI: doi:10.4199/C00060ED1V01Y201206PAC001
and 27 Related for: Proprotein convertase information
activity. Proproteinconvertases remove those chains and activate the protein. The prototypical proproteinconvertase is furin. Proproteinconvertases have...
Proproteinconvertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1. It is the 9th member of the proprotein...
Proproteinconvertase 1, also known as prohormone convertase, prohormone convertase 3, or neuroendocrine convertase 1 and often abbreviated as PC1/3 is...
Proproteinconvertase 2 (PC2) also known as prohormone convertase 2 or neuroendocrine convertase 2 (NEC2) is a serine protease and proprotein convertase...
that belongs to the subtilisin-like proproteinconvertase family. The members of this family are proproteinconvertases that process latent precursor proteins...
a small interfering RNA (siRNA) that acts as an inhibitor of a proproteinconvertase, specifically, inhibiting translation of the protein PCSK9. Inclisiran...
160-amino acid protein proglucagon. Proglucagon is then cleaved by proproteinconvertase 2 to glucagon (amino acids 33-61) in pancreatic islet α cells. In...
cleave the peptide precursors, which are small proteins. First, proproteinconvertases cut the precursor at specific sites to generate intermediates containing...
that target an important protein in the degradation of LDL called proproteinconvertase substilisin/kexin type 9 (PCSK9). These agents reduce LDL-C, increase...
Christian JL, Heasman J (February 2005). "XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins...
Proproteinconvertase subtilisin/kexin type 4 is an enzyme that in humans is encoded by the PCSK4 gene. GRCh38: Ensembl release 89: ENSG00000115257 –...
vesicles. In the granule, proinsulin is cleaved by proproteinconvertase 1/3 and proproteinconvertase 2, removing the middle part of the protein, called...
Proproteinconvertase subtilisin/kexin type 6 is an protease that in humans is encoded by the PCSK6 gene which is located in chromosome 15. Pcsk6 is a...
preproinsulin signal peptide signal peptide peptidase proproteinconvertase 1 (PC1) proproteinconvertase 2 (PC2) "Entrez Gene: INS insulin". Bell GI, Pictet...
determines the severity of the hypercholesterolemia. Mutations in the proproteinconvertase subtilisin/kexin type 9 (PCSK9) gene were linked to autosomal dominant...
prodynorphin. When prodynorphin is cleaved during processing by proproteinconvertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin...
Alirocumab Monoclonal antibody Type Whole antibody Source Human Target Proproteinconvertase subtilisin/kexin type 9 (PCSK9) Clinical data Trade names Praluent...
Proproteinconvertase subtilisin/kexin type 7 is an enzyme that in humans is encoded by the PCSK7 gene. The protein encoded by this gene belongs to the...
of Sparassis crispa (Wulf.) and Their Inhibitory Activities on ProproteinConvertase Subtilisin/Kexin Type 9 mRNA Expression". J. Agric. Food Chem. 65...
Proproteinconvertase subtilisin/kexin type 5 is an enzyme that in humans is encoded by the PCSK5 gene, found in chromosome 9q21.3 Two alternatively spliced...
the integration of sensory information from multiple modalities Proproteinconvertase, an enzyme family 6mm PPC (Palmisano & Pindel Cartridge), a family...
placenta and womb, and from the ovaries. Proproteinconvertase 1 converts prorenin into renin, but proproteinconvertase 2 does not. There is no evidence that...
neuroendocrine tissues. It functions as a chaperone protein for the proproteinconvertase PC2 by blocking the aggregation of this protein, and is required...
V, Gurbel PA, Tantry U, Lin Y, et al. (July 2015). "Effects of ProproteinConvertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia:...
where he identified Kex2 as the founding member of furin-like proproteinconvertases. In 1989, he completed his post-doctoral training with Richard Axel...
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