Sanford Burnham Prebys Medical Discovery Institute
Erkki Ruoslahti (born 16 February 1940 in Imatra, Finland) is a cancer researcher and distinguished professor at Sanford Burnham Prebys Medical Discovery Institute.[1] He moved from Finland to the United States in 1976.[2]
Ruoslahti made seminal contributions to biology of extracellular matrix and its receptors.[3]
He was one of the discoverers of fibronectin, an adhesion molecule and component of extracellular matrices, and he subsequently identified and cloned a number of other extracellular matrix components and adhesion molecules. In 1984, he identified the sequence within fibronectin that mediates cell attachment, called RGD for the amino acids of which it’s composed,[4] and isolated the cellular receptors that bind that sequence, now known as integrins.[5] The RGD discovery has led to the development of drugs for vascular thrombosis and cancer, among other diseases.[6]
Ruoslahti currently studies specific marker molecules in blood vessels. He introduced the concept of vascular "zip codes," the idea that each tissue bears molecular signatures that can be targeted by affinity ligands, and used in vivo peptide phage display to prove the concept and develop numerous tumor-homing peptides.[7]
^"Erkki Ruoslahti". Sanford Burnham Prebys Medical Discovery Institute. Retrieved October 30, 2017.
^Closing In on Cancer : In Search of a Cure, a La Jolla Research Center Reaches Into the Outer Limits Los Angeles Times
^
Ruoslahti, E; Pierschbacher, MD (1987). "New perspectives in cell adhesion: RGD and integrins". Science. 238 (4826): 491–497. Bibcode:1987Sci...238..491R. doi:10.1126/science.2821619. PMID 2821619.
^Pierschbacher, MD; Ruoslahti, E (1984). "Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule". Nature. 309 (5963): 30–33. Bibcode:1984Natur.309...30P. doi:10.1038/309030a0. PMID 6325925. S2CID 4371931.
^Dedhar, S; Ruoslahti, E; Pierschbacher, MD (1987). "A cell surface receptor complex for collagen type I recognizes the Arg-Gly-Asp sequence". J Cell Biol. 104 (3): 585–593. doi:10.1083/jcb.104.3.585. PMC 2114550. PMID 3469204.
^
Ley, K; Rivera-Nieves, J; Sandborn, WJ; Shattil, S (2016). "Integrin-based therapeutics: biological basis, clinical use and new drugs". Nat Rev Drug Discov. 15 (3): 173–183. doi:10.1038/nrd.2015.10. PMC 4890615. PMID 26822833.
^Ruoslahti, E. (2004). "Vascular zip codes in angiogenesis and metastasis". Biochem Soc Trans. 32 (3): 397–402. doi:10.1042/bst0320397. ISSN 0300-5127. PMID 15157146.
ErkkiRuoslahti (born 16 February 1940 in Imatra, Finland) is a cancer researcher and distinguished professor at Sanford Burnham Prebys Medical Discovery...
player Erkki Rapo (1946–2004), Finnish amateur autograph collector ErkkiRuoslahti (born 1940), Finnish physician and cancer researcher Erkki Ruuhinen...
(University of California, Berkeley). Previous Editors-in-Chief include: ErkkiRuoslahti (of Cell Regulation) and David Botstein and Keith Yamamoto (of MBoC)...
in the construction of tissues. He shared the 2005 Japan Prize with ErkkiRuoslahti for "fundamental contribution in elucidating the molecular mechanisms...
mediators of cell–matrix and cell–cell adhesion in physiology and disease. ErkkiRuoslahti Timothy A. Springer Clinical Yuk Ming Dennis Lo For the discovery of...
Recipient 2023 Demis Hassabis John M. Jumper 2022 Richard O. Hynes ErkkiRuoslahti Timothy A. Springer 2021 Karl Deisseroth Peter Hegemann Dieter Oesterhelt...
imaging, or release a therapeutic component. In 2002, Bhatia worked with ErkkiRuoslahti and Warren Chan to develop phage-derived peptide-targeted nanomaterials...
Nienhuis Deborah Prothrow-Stith James M. Roberts Gerald M. Rubin ErkkiRuoslahti Michael A. Savageau Thomas L. Schwenk Debra A. Schwinn Allen M. Spiegel...
Language Processing and Intelligent Image Processing. Masatoshi Takeichi ErkkiRuoslahti Japan United States for fundamental contribution in elucidating the...
Professor 2001 J. Gregor Sutcliffe, Professor 1999 E. Rothman 1998 ErkkiRuoslahti, Dr. 1997 Jeff Friedman, Professor 1995 Theodore Friedmann, Professor...
Hynes and Ruoslahti for integrins and Takeichi for cadherins." Massachusetts Institute of Technology Howard Hughes Medical Institute ErkkiRuoslahti (born...
founding editors of the journal Molecular Biology of the Cell, along with ErkkiRuoslahti and Keith Yamamoto. In 2013, Botstein was named chief scientific officer...
Sanford Burnham Prebys. September 8, 2022. Retrieved August 8, 2023. Ruoslahti, Erkki; Pierschbacher, Michael D. (23 October 1987). "New Perspectives in...
ISSN 1552-4965. PMID 31854488. S2CID 209417891. Pierschbacher, Michael D.; Ruoslahti, Erkki (1984-05-03). "Cell attachment activity of fibronectin can be duplicated...
ISSN 0042-6822. PMID 4902069. Teesalu, Tambet; Sugahara, Kazuki N.; Ruoslahti, Erkki (2012-01-01), "Chapter two - Mapping of Vascular ZIP Codes by Phage...
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