ANKRD1 information

ANKRD1
Identifiers
Aliases	ANKRD1, ALRP, C-193, CARP, CVARP, MCARP, bA320F15.2, ankyrin repeat domain 1
External IDs	OMIM: 609599; MGI: 1097717; HomoloGene: 8289; GeneCards: ANKRD1; OMA:ANKRD1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	90,921,087 bp
RNA expression pattern
	Top expressed in
	left ventricle; ; right lung; ; vena cava; ; gastrocnemius muscle; ; upper lobe of left lung; ; right ventricle; ; islet of Langerhans; ; left coronary artery; ; right coronary artery; ; ascending aorta;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; R-SMAD binding; transcription corepressor activity; p53 binding; histone deacetylase binding; titin binding; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; transcription factor binding;
Cellular component	cytoplasm; cytosol; transcription regulator complex; nucleoplasm; myofibril; nucleus; fibrillar center; I band;
Biological process	response to muscle stretch; cellular response to transforming growth factor beta stimulus; regulation of transcription by RNA polymerase II; cellular response to tumor necrosis factor; cellular response to organic cyclic compound; cardiac muscle tissue morphogenesis; negative regulation of transcription by RNA polymerase II; cellular response to mechanical stimulus; cellular response to interleukin-1; positive regulation of protein secretion; positive regulation of neuron projection development; positive regulation of apoptotic process; positive regulation of DNA damage response, signal transduction by p53 class mediator; cellular response to lipopolysaccharide; sarcomere organization; cellular response to hypoxia; negative regulation of DNA biosynthetic process; positive regulation of transcription by RNA polymerase II; regulation of lipid metabolic process; skeletal muscle cell differentiation; myoblast differentiation; transcription by RNA polymerase II; positive regulation of nucleic acid-templated transcription; skeletal muscle tissue development;
	Sources:Amigo / QuickGO
Orthologs
	27063
	107765
	ENSG00000148677
	ENSMUSG00000024803
	Q15327
	Q9CR42
	NM_014391
	NM_013468
	NP_055206
	NP_038496
	Wikidata
View/Edit Human	View/Edit Mouse

Ankyrin repeat domain-containing protein 1, or Cardiac ankyrin repeat protein is a protein that in humans is encoded by the ANKRD1 gene also known as CARP.^[4]^[5]^[6] CARP is highly expressed in cardiac and skeletal muscle, and is a transcription factor involved in development and under conditions of stress. CARP has been implicated in several diseases, including dilated cardiomyopathy, hypertrophic cardiomyopathy, and several skeletal muscle myopathies.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148677 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "UniProt". beta.uniprot.org. Retrieved 7 March 2022.
^ Chu W, Burns DK, Swerlick RA, Presky DH (June 1995). "Identification and characterization of a novel cytokine-inducible nuclear protein from human endothelial cells". J. Biol. Chem. 270 (17): 10236–45. doi:10.1074/jbc.270.17.10236. PMID 7730328.
^ "Entrez Gene: ANKRD1 ankyrin repeat domain 1 (cardiac muscle)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148677 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot1-4] "UniProt". beta.uniprot.org. Retrieved 7 March 2022.

[pmid7730328-5] Chu W, Burns DK, Swerlick RA, Presky DH (June 1995). "Identification and characterization of a novel cytokine-inducible nuclear protein from human endothelial cells". J. Biol. Chem. 270 (17): 10236–45. doi:10.1074/jbc.270.17.10236. PMID 7730328.

[entrez-6] "Entrez Gene: ANKRD1 ankyrin repeat domain 1 (cardiac muscle)".

ANKRD1 information

and 3 Related for: ANKRD1 information

ANKRD1

Titin

Ankyrin repeat