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Enolase 2 information


ENO2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesENO2, HEL-S-279, NSE, Enolase 2
External IDsOMIM: 131360 MGI: 95394 HomoloGene: 74414 GeneCards: ENO2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001975

NM_013509
NM_001302642
NM_001355220

RefSeq (protein)

NP_001966
NP_001966.1

NP_001289571
NP_038537
NP_001342149

Location (UCSC)Chr 12: 6.91 – 6.92 MbChr 6: 124.74 – 124.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene.[5][6] Gamma-enolase is a phosphopyruvate hydratase.

Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.[5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111674 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004267 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "ENO2 enolase 2 (gamma, neuronal)". NCBI Entrez Gene database.
  6. ^ Online Mendelian Inheritance in Man (OMIM): Enolase 2 - 131360

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phosphotransferase system. PEP is formed by the action of the enzyme enolase on 2-phosphoglyceric acid. Metabolism of PEP to pyruvic acid by pyruvate kinase...

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