Engineered chimeric antigen receptor (CAR)-T cell delivery is the methodology by which clinicians introduce the cancer-targeting therapeutic system of the CAR-T cell to the human body. CAR-T cells, which utilizes genetic modification of human T-cells to contain antigen binding sequences in addition to the receptor systems CD4 or CD8, are useful in direct targeting and elimination of cancer cells through cytotoxicity.
CAR-T cell delivery involves many varying modalities for implementation, spurring innovative biomedical research to address these modalities. These delivery mechanisms serve to address the limitations of CAR-T cells in translational experimentation and clinical trials, including shelf-life, off-target effects, and tumor infiltration.[1] As of April 2023, six CAR-T cell therapies are clinically approved by the FDA, all of which target hematologic (blood-based) cancers, including multiple myeloma and B-cell leukemias.[2][3] Novel engineered compound-based delivery methods, some of which are in clinical trials, aim to address limitations related to CAR-T cell delivery with the focus to target non-blood based cancers.[4][5]
^Sterner, Sterner, R.C., R.M. (2021). "CAR-T cell therapy: current limitations and potential strategies". Blood Cancer J. 11 (69): 69. doi:10.1038/s41408-021-00459-7. PMC 8024391. PMID 33824268.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^"CAR T Cells: Engineering Immune Cells to Treat Cancer". NCI. 6 December 2013. Retrieved 10 April 2023.
^"Approved Cellular and Gene Therapy Products". U.S. Food and Drug Administration (FDA). Retrieved 10 April 2023.
^Sagnella, Sharon M.; White, Amy L.; Yeo, Dannel; Saxena, Payal; van Zandwijk, Nico; Rasko, John E.J. (Aug 2022). "Locoregional delivery of CAR-T cells in the clinic". Pharmacological Research. 182: 106329. doi:10.1016/j.phrs.2022.106329. PMID 35772645.
^Ding, Yingyue; Wang, Yixin; Hu, Quanyin (Jun 2022). "Recent advances in overcoming barriers to cell‐based delivery systems for cancer immunotherapy". Exploration. 2 (3): 20210106. doi:10.1002/EXP.20210106. ISSN 2766-2098. PMC 10190958. PMID 37323702. S2CID 247494915.
and 27 Related for: Engineered CAR T cell delivery information
Engineered chimeric antigen receptor (CAR)-Tcelldelivery is the methodology by which clinicians introduce the cancer-targeting therapeutic system of...
hydrogen cars publicly available in select markets: the Toyota Mirai (2014–), which is the world's first commercially produced dedicated fuel cell electric...
extracted Tcells for later transfusion. Alternatively, Genetically engineeredTcells are created by harvesting Tcells and then infecting the Tcells with...
cells. It is an evolution of CARTcell therapy. Tcells are extracted from the patient and mixed with a genetically engineered virus that contains a cancer...
2016). "Southern California customers take delivery of n>ew 2017 Honda Clarity Fuel Cell sedan". Green Car Congress. Retrieved December 24, 2016. United...
Intracellular delivery is the process of introducing external materials into living cells. Materials that are delivered into cells include nucleic acids...
immunotherapies are Tcell therapies. Other therapies include CAR-T therapy, CAR-NK therapy, macrophage-based immunotherapy and dendritic cell therapy. Although...
A fuel cell is an electrochemical cell that converts the chemical energy of a fuel (often hydrogen) and an oxidizing agent (often oxygen) into electricity...
gun or biolistic particle delivery system is a device used to deliver exogenous DNA (transgenes), RNA, or protein to cells. By coating particles of a...
FCV-R (Fuel Cell Vehicle) concept car, which was unveiled at the 2011 Tokyo Motor Show and the Toyota FCV (Fuel Cell Vehicle) concept car, which was unveiled...
disease-causing genes. Suicide gene delivery introduces genetic sequences that induce an apoptotic response in cells, usually to kill cancerous growths...
genetically engineered to express a chimeric antibody receptor (CAR) against B cell antigen CD19 was shown to mediate regression of an advanced B cell lymphoma...
cells. It is an evolution of CAR-Tcell therapy. Tcells are extracted from the patient and mixed with a genetically engineered virus that contains a cancer...
Patent-Motorwagen. Commercial cars became widely available during the 20th century. One of the first cars affordable by the masses was the Ford Model T, begun in 1908...
pigmented epithelial (RPE) cells can also be engineered to express a cytokine of interest. RPE cells are ideal cytokine delivery systems because they are...
2009 Green Car Vision Award, 2011 Green Car of the Year, 2011 North American Car of the Year, 2011 World Green Car, 2011 SAE Best engineeredcar, 2012 European...
unveiled in September 2009. The fuel cell is designed for only 50,000 miles (80,000 km) of driving, but is engineered to be operable in subfreezing temperatures...
delivery vehicle), were entered by the American Bicycle Co. into the New York to Buffalo Endurance Contest of mid-September 1901. There were 36 cars in...
ability of CARTcells to infiltrate the tumor, several strategies have been developed to address this. Localized delivery of CARTcells in glioblastoma...
to attack cancer cells. Cell-based therapies focus on immunotherapies, mostly by engineering Tcells. Tcell receptors were engineered and 'trained' to...
Regenerative Medicine to lead a clinical trial using Tcellsengineered to express GD2-CARTcells for treatment of diffuse midline gliomas. Mackall holds...
Shares Info About Tesla's 4680 Battery Cells". "Tesla for $25,000? New Panasonic battery set to cut cost of electric cars". 11 March 2022. "Panasonic readies...
(a chimeric Tcell receptor, or "CAR-T") that reacts to the cancer, and are administered back to the person. The Tcells are engineered to target a protein...
This is a list of fuel cell vehicles (FCV), or fuel cell electric vehicles (FCEV), that use a fuel cell to power an electric drive system. For Hydrogen...
did not revive the pony car, instead offering smaller coupes such as the Dodge Daytona and Chrysler Conquest (a badge-engineered Mitsubishi Starion) in...
Touring car and tourer are both terms for open cars (i.e. cars without a fixed roof). "Touring car" is a style of open car built in the United States which...
Global Information