An illustration from von Economo's Die Encephalitis lethargica (1918) showing brain tissue of a monkey affected by Encephalitis lethargica, as seen under a microscope
Specialty
Infectious diseases, neurology
Causes
Unknown
Frequency
Unknown
Encephalitis lethargica is an atypical form of encephalitis. Also known as "sleeping sickness" or "sleepy sickness" (distinct from tsetse fly–transmitted sleeping sickness), it was first described in 1917 by neurologist Constantin von Economo[2][3] and pathologist Jean-René Cruchet.[4] The disease attacks the brain, leaving some victims in a statue-like condition, speechless and motionless.[5] Between 1915 and 1926,[6] an epidemic of encephalitis lethargica spread around the world. The exact number of people infected is unknown, but it is estimated that more than one million people contracted the disease during the epidemic, which directly caused more than 500,000 deaths.[7][8][9] Most of those who survived never recovered their pre-morbid vigour.
^Berger JR, Vilensky JA (2014). "Encephalitis lethargica (von Economo's encephalitis)". Neurovirology. Handbook of Clinical Neurology. Vol. 123. pp. 745–761. doi:10.1016/B978-0-444-53488-0.00036-5. ISBN 978-0444534880. PMID 25015515.
^Economo's disease at Who Named It?
^von Economo, K. (May 10, 1917). "Die Encephalitis lethargica". Wiener klinische Wochenschrift [Vienna clinical weekly] (in German). 30. Leipzig and Vienna: Franz Deuticke 1918: 581–585.
^Cruchet, R; Moutier, J; Calmettes, A (1917). "Quarante cas d'encéphalomyélite subaiguë" [Forty cases of (subacute) encephalitis lethargica]. Bull Soc Med Hôp (in French). 41. Paris: 614–616.
^Dale, Russell C.; Church, Andrew J.; Surtees, Robert A.H.; Lees, Andrew J.; Adcock, Jane E.; Harding, Brian; Neville, Brian G. R.; Giovannoni, Gavin (2004). "Encephalitis Lethargica Syndrome: 20 New Cases and Evidence of Basal Ganglia Autoimmunity". Brain. 127 (1): 21–33. doi:10.1093/brain/awh008. PMID 14570817.
^"Encephalitis lethargica" at Dorland's Medical Dictionary
^Ravenholt, R.T.; Foege, William H. (1982-10-16). "1918 Influenza, encephalitis lethargica, Parkinsonism". The Lancet. 320 (8303): 860–864. doi:10.1016/S0140-6736(82)90820-0. ISSN 0140-6736. PMID 6126720. S2CID 45138249. Originally published as Volume 2, Issue 8303. Archived from the original on 2021-07-12. Retrieved 2020-12-23.
^McCall, Sherman; Vilensky, Joel A.; Gilman, Sid; Taubenberger, Jeffery K. (May 2008). "The relationship between encephalitis lethargica and influenza: A critical analysis". Journal of Neurovirology. 14 (3): 177–185. doi:10.1080/13550280801995445. ISSN 1355-0284. PMC 2778472. PMID 18569452.
^Hoffman, Leslie A.; Vilensky, Joel A. (2017-08-01). "Encephalitis lethargica: 100 years after the epidemic". Brain. 140 (8): 2246–2251. doi:10.1093/brain/awx177. ISSN 0006-8950. PMID 28899018. Archived from the original on 2021-03-04. Retrieved 2020-12-23.
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Encephalitislethargica is an atypical form of encephalitis. Also known as "sleeping sickness" or "sleepy sickness" (distinct from tsetse fly–transmitted...
though the cause of encephalitislethargica is not currently known. From 1917 to 1928, an epidemic of encephalitislethargica occurred worldwide. People...
neurologist of Romanian origin. He is mostly known for his discovery of encephalitislethargica and his atlas of cytoarchitectonics of the cerebral cortex. Constantin...
epidemic of encephalitislethargica, as it appears, he was investigating this disorder. This epidemic involved inflammation of the brain (encephalitis), and...
coprolalia seen in tic disorders, but has been seen in people with encephalitislethargica, alcohol use disorder, and carbon monoxide poisoning. It was first...
Ravenholt, R. T; Foege, WilliamH (1982-10-16). "1918 Influenza, EncephalitisLethargica, Parkinsonism". The Lancet. Originally published as Volume 2, Issue...
many as 675,000 Americans. Between 1915 and 1926, an epidemic of encephalitislethargica spread around the world affecting nearly five million people. 8...
it to catatonic patients who survived the 1919–1930 epidemic of encephalitislethargica. Leonard Lowe (Robert De Niro) and the rest of the patients are...
with similar behavioral problems who had survived the epidemic of encephalitislethargica from 1917 to 1918 and the pandemic of influenza from 1919 to 1920...
worked with a group of survivors of the 1920s sleeping sickness encephalitislethargica, who had been unable to move on their own for decades. His treatment...
Enterococcus spp. Presumably, diplococcus has been implicated in encephalitislethargica. Phylum: Proteobacteria Class: Betaproteobacteria Order: Neisseriales...
dystonia parkinsonism (Lubag syndrome) Creutzfeldt–Jakob disease Encephalitislethargica HIV infection and AIDS Evidence exists to show a link between exposure...
years 1969 American Fell into a catatonic stupor resulting from encephalitislethargica. In 1969, Dr. Oliver Sacks managed to awaken him and a few other...
in populations. The flu has also been linked to the outbreak of encephalitislethargica in the 1920s. Survivors faced an elevated mortality risk. Some...
cortical blindness is most often caused by perinatal ischemic stroke, encephalitis, and meningitis. Rarely, a patient with acquired cortical blindness may...
a higher prevalence for men due to the sleep apnea syndromes". Encephalitislethargica Reticular formation Sleep medicine Somnolence "Sleep Disorders"...
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