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Emodepside information


Emodepside
Clinical data
AHFS/Drugs.comInternational Drug Names
ATCvet code
  • QP52AX60 (WHO) (combination with toltrazuril)
Legal status
Legal status
  • CA: ℞-only
Identifiers
CAS Number
  • 155030-63-0 checkY
PubChem CID
  • 6918632
ChemSpider
  • 5293825 checkY
UNII
  • YZ647Y5GC9
ChEBI
  • CHEBI:78739 ☒N
ChEMBL
  • ChEMBL2104404 ☒N
CompTox Dashboard (EPA)
  • DTXSID50165799 Edit this at Wikidata
ECHA InfoCard100.123.218 Edit this at Wikidata
Chemical and physical data
FormulaC60H90N6O14
Molar mass1119.408 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CC(C)C[C@H]1C(=O)O[C@H](Cc2ccc(N3CCOCC3)cc2)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](Cc2ccc(N3CCOCC3)cc2)C(=O)N(C)[C@@H](CC(C)C)C(=O)O[C@H](C)C(=O)N1C
InChI
  • InChI=1S/C60H90N6O14/c1-37(2)31-47-57(71)77-41(9)53(67)61(11)50(34-40(7)8)60(74)80-52(36-44-17-21-46(22-18-44)66-25-29-76-30-26-66)56(70)64(14)48(32-38(3)4)58(72)78-42(10)54(68)62(12)49(33-39(5)6)59(73)79-51(55(69)63(47)13)35-43-15-19-45(20-16-43)65-23-27-75-28-24-65/h15-22,37-42,47-52H,23-36H2,1-14H3/t41-,42-,47+,48+,49+,50+,51-,52-/m1/s1 checkY
  • Key:ZMQMTKVVAMWKNY-YSXLEBCMSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Emodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, is licensed for use in cats[1] and belongs to the class of drugs known as the octadepsipeptides,[2] a relatively new class of anthelmintic (research into these compounds began in the early 1990s),[3] which are suspected to achieve their anti-parasitic effect by a novel mechanism of action due to their ability to kill nematodes resistant to other anthelmintics.[4]

  1. ^ "Profender? Spot-on at a glance". Archived from the original on 2007-01-11. Retrieved 2007-01-10.
  2. ^ Willson J, Amliwala K, Harder A, Holden-Dye L, Walker RJ (January 2003). "The effect of the anthelmintic emodepside at the neuromuscular junction of the parasitic nematode Ascaris suum". Parasitology. 126 (Pt 1): 79–86. doi:10.1017/S0031182002002639. PMID 12613766. S2CID 21831523.
  3. ^ Cite error: The named reference Harder_2005 was invoked but never defined (see the help page).
  4. ^ Harder A, Schmitt-Wrede HP, Krücken J, Marinovski P, Wunderlich F, Willson J, et al. (September 2003). "Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action". International Journal of Antimicrobial Agents. 22 (3): 318–331. doi:10.1016/S0924-8579(03)00219-X. PMID 13678839.

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Emodepside

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Camellia

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sterile PF1022 produces a metabolite named PF1022A that is used to produce emodepside, an anthelmintic drug. Mainly due to habitat destruction, several camellias...

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Toxocara cati

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of anthelmintics that will kill the adult worms, including Ivermectin, emodepside, fenbendazole, milbemycin, and moxidectin. However, most drugs are ineffective...

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Anthelmintic

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against flatworms (e.g., tapeworms and schistosoma) Octadepsipeptides (e.g. Emodepside) – effective against a variety of gastrointestinal helminths Monepantel...

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Praziquantel

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Garden; licensed by COTS Koi) for aquarium use Profender (combination with emodepside) (Bayer) for veterinary use Tape Worm Tabs (Trade Winds) for veterinary...

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Octadepsipeptide

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Octadepsipeptide may refer to: Emodepside Anthelmintic This disambiguation page lists articles associated with the title Octadepsipeptide. If an internal...

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ATCvet code QP52

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QP52AX07 Butylchoride QP52AX08 Thiacetarsamid QP52AX09 Monepantel QP52AX60 Emodepside and toltrazuril Empty group Empty group Empty group Empty group "The ATCvet...

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Nematode infection in dogs

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weeks after the event. For treatment against roundworms, drugs based on emodepside, fenbendazole, flubendazole, mebendazole, milbemycin oxime, moxidectin...

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Cat worm infections

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moxidectin, pyrantel and selamectin are approved in Germany for domestic cats. Emodepside, eprinomectin, and selamectin may be used in pregnant and lactating cats...

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Halovir

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agents (examples of such include β-lactams, daptomycin, echinocandins, emodepside, bleomycin, cyclosporine, and bialaphos). Peptaibols are a family of linear...

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