ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000175832 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000017724 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Isobe M, Yamagishi F, Yoshida K, Higashino F, Fujinaga K (Jul 1995). "Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21". Genomics. 28 (2): 357–9. doi:10.1006/geno.1995.1158. PMID 8530053.
ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors....
Known motif – from protein with 100% identical DBD – in vitro [217] VGGAWR ETV4 ENSG00000175832 Ets Known motif – High-throughput in vitro [218] RCCGGAWGY...
Rhodes DR, Smith LR, Roulston D, Helgeson BE, et al. (April 2006). "TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer". Cancer...
part of an ETS transcription factor family gene (i.e. a FLI1, ERG, ETV1, ETV4, or FEV gene). These fusion genes are the EWSR1–FLI1 fusion gene in 80-85%...
Lessnick SL, Winstanley M (August 2021). "Identification of a novel FUS/ETV4 fusion and comparative analysis with other Ewing sarcoma fusion proteins"...
hydride transfer from NADPH to the carbon 5 position of the steroid substrate. ETV4 family members bind to ETS DNA-binding sites and both regulate their own...
have also been shown to be associated with GAB1-ABL1, GTF2I-NCOA2, NCOA2-ETV4, ETV4-AHRR, and NAB2-STAT6 fusion genes. The diagnosis of AFST depends on its...
USF1 and other transcription factors, including SP1, PEA3 (also known as ETV4) and MTF1, also leads to cooperative transcriptional regulation. For instance...
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