SRD5A1 information

SRD5A1
Identifiers
Aliases	SRD5A1, S5AR 1, steroid 5 alpha-reductase 1
External IDs	OMIM: 184753; MGI: 98400; HomoloGene: 37426; GeneCards: SRD5A1; OMA:SRD5A1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	6,674,386 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	69,759,561 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; endothelial cell; ; gingival epithelium; ; vulva; ; hair follicle; ; Brodmann area 23; ; jejunal mucosa; ; skin of arm; ; right lobe of liver; ; oral cavity;
	Top expressed in
	transitional epithelium of urinary bladder; ; gastrula; ; decidua; ; left lobe of liver; ; genital tubercle; ; otolith organ; ; utricle; ; otic vesicle; ; right kidney; ; interventricular septum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors; cholestenone 5-alpha-reductase activity; amide binding; NADPH binding; electron transfer activity; oxidoreductase activity; 3-oxo-5-alpha-steroid 4-dehydrogenase activity;
Cellular component	cytoplasm; integral component of membrane; organelle membrane; endoplasmic reticulum membrane; cell body fiber; membrane; myelin sheath; intracellular membrane-bounded organelle; neuronal cell body; endoplasmic reticulum; perinuclear region of cytoplasm;
Biological process	response to fungicide; cell differentiation; pituitary gland development; male gonad development; response to estradiol; response to organic cyclic compound; circadian sleep/wake cycle, REM sleep; androgen metabolic process; thalamus development; lipid metabolism; cellular response to testosterone stimulus; diterpenoid metabolic process; response to testosterone; cellular response to starvation; cellular response to growth factor stimulus; cellular response to estradiol stimulus; cellular response to organic cyclic compound; sex differentiation; serotonin metabolic process; cellular response to dexamethasone stimulus; response to estrogen; cellular response to epinephrine stimulus; sex-determination system; response to growth hormone; spinal cord development; hypothalamus development; cerebral cortex development; cellular response to insulin stimulus; urogenital system development; liver development; bone development; hippocampus development; response to muscle activity; response to follicle-stimulating hormone; cellular response to cAMP; steroid metabolic process; androgen biosynthetic process; male genitalia development; female genitalia development; progesterone metabolic process; steroid biosynthetic process; electron transport chain; androgen catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6715
	78925
	ENSG00000145545
	ENSMUSG00000021594
	P18405
	Q68FF9
	NM_001047; NM_001324322; NM_001324323
	NM_175283
	NP_001038; NP_001311251; NP_001311252
	NP_780492
	Wikidata
View/Edit Human	View/Edit Mouse

3-Oxo-5α-steroid 4-dehydrogenase 1 is an enzyme that in humans is encoded by the SRD5A1 gene.^[5] It is one of three forms of steroid 5α-reductase.

Steroid 5α-reductase (EC 1.3.99.5) catalyzes, among other reactions, the conversion of testosterone into the more potent androgen, 5α-dihydrotestosterone (DHT). The SRD5A1, SRD5A2, and SRD5A3 genes in humans all encode 5α-reductase isozymes.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145545 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021594 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jenkins EP, Hsieh CL, Milatovich A, Normington K, Berman DM, Francke U, Russell DW (December 1991). "Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue". Genomics. 11 (4): 1102–1112. doi:10.1016/0888-7543(91)90038-G. PMID 1686016.
^ "Entrez Gene: SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145545 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021594 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1686016-5] Jenkins EP, Hsieh CL, Milatovich A, Normington K, Berman DM, Francke U, Russell DW (December 1991). "Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue". Genomics. 11 (4): 1102–1112. doi:10.1016/0888-7543(91)90038-G. PMID 1686016.

[entrez-6] "Entrez Gene: SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)".

SRD5A1 information

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SRD5A1

Androgen backdoor pathway

Dihydrotestosterone

AKR1C2