Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. EGR2 (also termed Krox20) is a transcription regulatory factor, containing three zinc finger DNA-binding sites, and is highly expressed in a population of migrating neural crest cells.[5][6][7] It is later expressed in the neural crest derived cells of the cranial ganglion. The protein encoded by Krox20 contains two cys2his2-type zinc fingers. Krox20 gene expression is restricted to the early hindbrain development.[6][8] It is evolutionarily conserved in vertebrates, humans, mice, chicks, and zebra fish.[9] In addition, the amino acid sequence and most aspects of the embryonic gene pattern is conserved among vertebrates, further implicating its role in hindbrain development.[7][10][11][12] When the Krox20 is deleted in mice, the protein coding ability of the Krox20 gene (including the DNA-binding domain of the zinc finger) is diminished. These mice are unable to survive after birth and exhibit major hindbrain defects.[6][8] These defects include but are not limited to defects in formation of cranial sensory ganglia, partial fusion of the trigeminal nerve (V) with the facial (VII) and auditory (VII) nerves, the proximal nerve roots coming off of these ganglia were disorganized and intertwined among one another as they entered the brainstem, and there was fusion of the glossopharyngeal (IX) nerve complex.[13][14][15]
^ abcGRCh38: Ensembl release 89: ENSG00000122877 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037868 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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^ abcCite error: The named reference Swiatek_1993 was invoked but never defined (see the help page).
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growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. EGR2 (also termed Krox20) is a transcription regulatory factor, containing...
continuative study discovered that the Ewing sarcoma susceptibility gene EGR2, which is located within the chromosome 10 susceptibility locus, is regulated...
J (May 2007). "Neuropathy-Associated Egr2 Mutants Disrupt Cooperative Activation of Myelin Protein Zero by Egr2 and Sox10". Mol. Cell. Biol. 27 (9): 3521–29...
microsatellite which binds a transcription factor, which in turn activates the EGR2 gene which drives the cancer. In addition, other GGAA microsatellites may...
highly expressed throughout organoid development. However, hindbrain markers EGR2 and ISL1 show early presence but a decrease in the later stages. This imbalance...
pathways and dysfunction of transcriptional factors like KNOX20, SOX10 and EGR2. PMP22 has been found to interact with several different factors, some of...
zinc finger transcription factors. Members of the family include: EGR1, EGR2, EGR3 and EGR4 Gómez-Martín D, Díaz-Zamudio M, Galindo-Campos M, Alcocer-Varela...
potential molecular convergence involves the early growth response gene-2 (EGR2). EGR2 is the only gene in the EGR family that is restricted to the central...
Unoki M, Nakamura Y (Aug 2001). "Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway". Oncogene. 20 (33): 4457–65...
various stimuli. Also was shown its role in T-cell clonal anergy downstream of Egr2, where NDRG1 is upregulated in the absence of costimulation to inhibit subsequent...
Unoki M, Nakamura Y (Aug 2001). "Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway". Oncogene. 20 (33): 4457–65...
Gilardi-Hebenstreit P, Rossert J, Ruggiero F, Duprez D (February 2011). "EGR1 and EGR2 involvement in vertebrate tendon differentiation". The Journal of Biological...
the mammalian growth regulated early growth response protein 1 (EGR1) and (EGR2) proteins. Mutations of Wilms' tumor suppressor gene1 (WT1) are associated...
Venken K, Di Maria E, Bellone E, et al. (2003). "Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies". Neurogenetics...
Venken K, Di Maria E, Bellone E, et al. (2003). "Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies". Neurogenetics...
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