Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Dynorphin A is a dynorphin, an endogenous opioid peptide that activates the κ-opioid receptor.[2] Its amino acid sequence is Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys.
Dynorphin A1–8 is a truncated form of dynorphin A with the amino acid sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile.[3][4] Dynorphin A1–8 is an agonist at the mu-, kappa-, and delta-opioid receptors;[4] it has the highest binding affinity for the kappa-opioid receptor.[4] Structures of dynorphin A bound to the κ-opioid receptor have been reported.[2][5]
^Dynorphin 1-13 - Compound Summary, PubChem.
^ abWang, Yue; Zhuang, Youwen; DiBerto, Jeffrey F.; Zhou, X. Edward; Schmitz, Gavin P.; Yuan, Qingning; Jain, Manish K.; Liu, Weiyi; Melcher, Karsten; Jiang, Yi; Roth, Bryan L.; Xu, H. Eric (2023-01-12). "Structures of the entire human opioid receptor family". Cell. 186 (2): 413–427.e17. doi:10.1016/j.cell.2022.12.026. PMID 36638794. S2CID 255750597.
^"Dynorphin A 1-8". HMDB Version 4.0. Human Metabolome Database. 27 September 2017. Retrieved 20 October 2017.
^ abc"Dynorphin A-(1-8): Biological activity". IUPHAR/BPS Guide to PHARMACOLOGY. International Union of Basic and Clinical Pharmacology. Retrieved 20 October 2017. Principal endogenous agonists at κ receptor
^Chen, Yuxiang; Chen, Bo; Wu, Tingting; Zhou, Fangfang; Xu, Fei (2022-08-05). "Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A". Protein & Cell. 14 (6): 464–468. doi:10.1093/procel/pwac033. ISSN 1674-800X. PMC 10246719. PMID 37285260.
dynorphin.” “Big Dynorphin” is a 32-amino acid molecule consisting of both dynorphinA and dynorphin B. DynorphinA, dynorphin B, and big dynorphin all...
DynorphinA is adynorphin, an endogenous opioid peptide that activates the κ-opioid receptor. Its amino acid sequence is Tyr-Gly-Gly-Phe-Leu-Arg-Arg-...
Big dynorphin is an endogenous opioid peptide of the dynorphin family that is composed of both dynorphinA and dynorphin B. Big dynorphin has the amino...
dynorphinA (PDYN, P01213) "DynorphinA 1–8". HMDB Version 4.0. Human Metabolome Database. 27 September 2017. Retrieved 20 October 2017. DynorphinA (1–8)...
Dynorphin B, also known as rimorphin, is a form of dynorphin and an endogenous opioid peptide with the amino acid sequence Tyr-Gly-Gly-Phe-Leu-Arg-Arg...
Leumorphin, also known as dynorphin B1–29, is a naturally occurring endogenous opioid peptide. Derived as a proteolytic cleavage product of residues 226-254...
Kisspeptin, neurokinin B, and dynorphin (KNDy) neurons are neurons in the hypothalamus of the brain that are central to the hormonal control of reproduction...
Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a treatment for depression and pain...
species. Neurokinin B is expressed along with the peptides kisspeptin and dynorphinA in the neuronal cells of the arcuate nucleus. Five exon segments in the...
other names, is a morphinan opioid substance synthesized from the dried latex of the Papaver somniferum plant; it is mainly used as a recreational drug...
of opioid peptides produced by the body: enkephalins, β-endorphin, and dynorphins. The met-enkephalin peptide sequence is coded for by the enkephalin gene;...
Morphine, formerly also called morphia, is a strong opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium...
(enkephalins, dynorphin, endorphin) do not bind specifically to any particular opioid receptor. Receptor binding of the opioid causes a cascade leading...
Adderall and Mydayis are trade names for a combination drug called mixed amphetamine salts containing four salts of amphetamine. The mixture is composed...
Black tar heroin, also known as black dragon, is a form of heroin that is sticky like tar or hard like coal. Its dark color is the result of crude processing...
Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins...
Dextroamphetamine (INN:dexamfetamine) is a potent central nervous system (CNS) stimulant and enantiomer of amphetamine that is prescribed for the treatment...
injected at a precisely controlled dosage. A little of it, taken as much as a grain of ervum is a pain-easer, and a sleep-causer, and a digester...but...
(−183.2 °C; −297.7 °F), it has lattice parameters a = 7.10 Å, b = 7.29 Å, c = 10.81 Å, and β = 97.29°. A 2011 study into the destruction of methamphetamine...
expression of AMPA receptor subunit GluR2 and also decreases expression of dynorphin, thereby enhancing sensitivity to reward. DNA damage is increased in the...
Loperamide, sold under the brand name Imodium, among others, is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea...
increasing to a lesser extent. According to two medical reviews, ΔFosB has been implicated in causing both increases and decreases in dynorphin expression...
interplay between the neurotransmitters kisspeptin, neurokinin B, and dynorphin, which are found in KNDy neurons in the infundibular nucleus. Decreased...
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