Series of chemical reactions by which compounds exchange ligands
"Dissociative reaction" redirects here. For the disorder formerly known as dissociative reaction, see dissociative identity disorder.
In chemistry, dissociative substitution describes a reaction pathway by which compounds interchange ligands. The term is typically applied to coordination and organometallic complexes, but resembles the SN1 mechanism in organic chemistry. This pathway can be well described by the cis effect, or the labilization of CO ligands in the cis position. The opposite pathway is associative substitution, being analogous to SN2 pathway. Pathways that are intermediate between the pure dissociative and pure associative pathways are called interchange mechanisms.[1][2]
Complexes that undergo dissociative substitution are often coordinatively saturated and often have octahedral molecular geometry. The entropy of activation is characteristically positive for these reactions, which indicates that the disorder of the reacting system increases in the rate-determining step.
^Basolo, F.; Pearson, R. G. "Mechanisms of Inorganic Reactions." John Wiley: New York: 1967. ISBN 0-471-05545-X
^R. G. Wilkins "Kinetics and Mechanism of Reactions of Transition Metal Complexes," 2nd Edition, VCH, Weinheim, 1991. ISBN 1-56081-125-0
and 24 Related for: Dissociative substitution information
In chemistry, dissociativesubstitution describes a reaction pathway by which compounds interchange ligands. The term is typically applied to coordination...
A substitution reaction (also known as single displacement reaction or single substitution reaction) is a chemical reaction during which one functional...
amnesia. According to Pender (1972), "the state has been designated as dissociative anesthesia since the patient truly seems disassociated from his environment...
inorganic chemistry, the SN1 reaction is often known as the dissociativesubstitution. This dissociation pathway is well-described by the cis effect. A reaction...
is dissociativesubstitution, being analogous to the Sn1 pathway. Intermediate pathways exist between the pure associative and pure dissociative pathways...
mechanisms are recognized: associative substitution or by dissociativesubstitution. Associative substitution closely resembles the SN2 mechanism in organic...
Dissociative amnesia or psychogenic amnesia is a dissociative disorder "characterized by retrospectively reported memory gaps. These gaps involve an inability...
compounds undergo several important reactions: associative and dissociativesubstitution oxidative addition and reductive elimination transmetalation migratory...
differ by a factor of 109 also. Water exchange usually follows a dissociativesubstitution pathway, so the rate constants indicate first order reactions...
a dissociation constant (KD) is a specific type of equilibrium constant that measures the propensity of a larger object to separate (dissociate) reversibly...
disorder. It is in the morphinan class of medications with sedative, dissociative, and stimulant properties (at lower doses). Dextromethorphan does not...
alternative to aromatic substitution is electrophilic aliphatic substitution. It is similar to the nucleophilic aliphatic substitution and also has two major...
In chemistry, an acid dissociation constant (also known as acidity constant, or acid-ionization constant; denoted K a {\displaystyle K_{a}} ) is a quantitative...
has been designated as dissociative anesthesia since the patient truly seems disassociated from his environment." Dissociative symptoms include the disruption...
In chemistry, SNi (substitution nucleophilic internal) refers to a specific, regio-selective but not often encountered reaction mechanism for nucleophilic...
psychoactive drugs, consisting of opiate analgesics, cough suppressants, and dissociative hallucinogens, among others. Typical examples include compounds such...
water breaks one or more chemical bonds. The term is used broadly for substitution, elimination, and solvation reactions in which water is the nucleophile...
known in its use as a street drug as angel dust among other names, is a dissociative anesthetic mainly used recreationally for its significant mind-altering...
methylamine in ketamine synthesis) in the clandestine synthesis of cyclidine dissociative anesthetic agents (the analogue of ketamine which is missing the 2-chloro...
Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a treatment for depression and pain...
A blood substitute (also called artificial blood or blood surrogate) is a substance used to mimic and fulfill some functions of biological blood. It aims...
drugs, for their dissociative, hallucinogenic, and euphoriant properties. When used recreationally, they are classified as dissociative drugs. NMDA receptor...
4-Substituted-2,5-dimethoxyamphetamines (DOx) is a chemical class of substituted amphetamine derivatives featuring methoxy groups at the 2- and 5- positions...
other atoms, for example chlorine or another halogen: this is called a substitution reaction. An example is the conversion of methane to chloroform using...
Global Information