Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug with atropine for the treatment of diarrhea. Diphenoxylate is an opioid and acts by slowing intestinal contractions; the atropine is present to prevent drug abuse and overdose. It should not be given to children due to the risk that they will stop breathing and should not be used in people with Clostridium difficile infection.
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
Diphenoxylate is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug with atropine for the treatment of diarrhea...
(for example, infection or malabsorption), but it does decrease motility. Examples include diphenoxylate, loperamide, and eluxadoline. Propulsive v t e...
colitis, or bacterial enterocolitis. Loperamide is often compared to diphenoxylate. Studies suggest that loperamide is more effective and has lower neural...
with atropine, to treat diarrhea. It is the principal metabolite of diphenoxylate.: 558 It was first approved in the US in 1978 and in 1980 in the former...
containing the equivalent of more than 90 mg of codeine per dosage unit; Diphenoxylate (pure) Fentanyl and most other strong pure opioid agonists, e.g. levorphanol...
and structural relatives of piritramide in clinical use include the diphenoxylate family, fentanyl (both Janssen discoveries) and somewhat more distantly...
potentially addictive drugs, particularly antidiarrhea opioid drugs such as diphenoxylate or difenoxin, wherein the secretion-reducing effects of the atropine...
need to receive fluids intravenously. Antidiarrheal drugs (such as diphenoxylate or loperamide) may prolong the infection and should not be used. Antibiotics...
include loperamide (Imodium), bismuth subsalicylate (Pepto-Bismol), diphenoxylate with atropine (Lomotil), and opiates such as paregoric, tincture of...
droperidol and etomidate. One of the anti-diarrheal drugs he developed, diphenoxylate (Lomotil), was used in the Apollo program. In 1959, Janssen synthesized...
loperamide (which is available without a prescription for milder diarrhea), diphenoxylate, paregoric, or even laudanum are more frequently used to treat severe...
an anaesthetic, as well as haloperidol, piritramide, the loperamide-diphenoxylate series and other important drugs. Dextromoramide was much favoured by...
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