Difenoxin information

Difenoxin
Clinical data
Other names	Difenoxin, Motofen
AHFS/Drugs.com	International Drug Names
ATC code	A07DA04 (WHO) ;
Legal status
Legal status	AU: S8 (Controlled drug); BR: Class A1 (Narcotic drugs); CA: Schedule I; DE: Prescription only (Anlage II for higher doses) if combined with atropine sulphate; US: Schedule I (by itself); Schedule IV-V (with atropine);
Identifiers
	IUPAC name 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid;
CAS Number	28782-42-5 ; HCl: 35607-36-4 ;
PubChem CID	34328;
IUPHAR/BPS	7592;
DrugBank	DB01501 ;
ChemSpider	31620 ;
UNII	3ZZ5BJ9F2Q; HCl: VQZ63K01IW ;
KEGG	D03809 ;
ChEBI	CHEBI:4534 ;
ChEMBL	ChEMBL1201321 ;
CompTox Dashboard (EPA)	DTXSID0022931 ;
Chemical and physical data
Formula	C28H28N2O2
Molar mass	424.544 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(CCN1CCC(CC1)(C(O)=O)C2=CC=CC=C2)(C3=CC=CC=C3)(C4=CC=CC=C4)C#N;
	InChI InChI=1S/C28H28N2O2/c29-22-28(24-12-6-2-7-13-24,25-14-8-3-9-15-25)18-21-30-19-16-27(17-20-30,26(31)32)23-10-4-1-5-11-23/h1-15H,16-21H2,(H,31,32) ; Key:UFIVBRCCIRTJTN-UHFFFAOYSA-N ;
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Difenoxin (Motofen, R-15403) is an opioid drug used, often in combination with atropine, to treat diarrhea.^[2] It is the principal metabolite of diphenoxylate.^[3]^[4]^: 558

It was first approved in the US in 1978^[5] and in 1980 in the former West Germany.^[6]^: 485

Difenoxin crosses the blood brain barrier and induces some euphoria; it is often sold with or administered with atropine to reduce the potential for abuse and overdose.^[2]

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ ^a ^b Scarlett Y (January 2004). "Medical management of fecal incontinence". Gastroenterology. 126 (1 Suppl 1): S55-63. doi:10.1053/j.gastro.2003.10.007. PMID 14978639. S2CID 39136903.
^ United Nations Department of Economic and Social Affairs (2005). "Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments" (PDF). New York: United Nations. p. 109. Retrieved 5 November 2020.
^ Katzung BG, Masters SB, Trevor AJ (2012). Basic and Clinical Pharmacology (12th ed.). New York: McGraw-Hill Medical. ISBN 9780071764025.
^ "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Retrieved 5 November 2020.
^ Sittig M (1988). Pharmaceutical Manufacturing Encyclopedia. Vol. 1–2 (2nd ed.). William Andrew Publishing/Noyes. ISBN 9780815511441.

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2004rev-2] Scarlett Y (January 2004). "Medical management of fecal incontinence". Gastroenterology. 126 (1 Suppl 1): S55-63. doi:10.1053/j.gastro.2003.10.007. PMID 14978639. S2CID 39136903.

[WHO-3] United Nations Department of Economic and Social Affairs (2005). "Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments" (PDF). New York: United Nations. p. 109. Retrieved 5 November 2020.

[Katzung-4] Katzung BG, Masters SB, Trevor AJ (2012). Basic and Clinical Pharmacology (12th ed.). New York: McGraw-Hill Medical. ISBN 9780071764025.

[5] "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Retrieved 5 November 2020.

[6] Sittig M (1988). Pharmaceutical Manufacturing Encyclopedia. Vol. 1–2 (2nd ed.). William Andrew Publishing/Noyes. ISBN 9780815511441.

Difenoxin information

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Difenoxin

Diphenoxylate

Atropine

Opioid

Motofen

Controlled Substances Act

Brazilian Controlled Drugs and Substances Act

Single Convention on Narcotic Drugs

Drug policy of India

ATC code A07

Drugs controlled by the UK Misuse of Drugs Act

List of opioids

Controlled Drugs and Substances Act

Misuse of Drugs Act 1977