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Diminazene information


Diminazene
Ball-and-stick model of diminazen
Clinical data
Trade namesAzidin, Berenil, Ganasag, Pirocide
Other names4,4'-(1-Triazene-1,3-diyl)bis(benzenecarboximidamide)
Routes of
administration		IM, SC
ATCvet code
  • QP51DF01 (WHO)
Legal status
Legal status
  • Veterinary use only
Identifiers
IUPAC name
  • 4-[2-(4-Carbamimidoylphenyl)iminohydrazinyl]benzenecarboximidamide
CAS Number
  • 536-71-0
  • aceturate: 908-54-3
PubChem CID
  • 2354
ChemSpider
  • 2264
UNII
  • Y5G36EEA5Z
  • aceturate: JI8SAD85NO
ChEBI
  • CHEBI:81724 checkY
ChEMBL
  • ChEMBL124025 checkY
CompTox Dashboard (EPA)
  • DTXSID7043792 Edit this at Wikidata
ECHA InfoCard100.007.860 Edit this at Wikidata
Chemical and physical data
FormulaC14H15N7
Molar mass281.323 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • C1=CC(=CC=C1C(=N)N)N/N=N/C2=CC=C(C=C2)C(=N)N
InChI
  • InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20)
  • Key:XNYZHCFCZNMTFY-UHFFFAOYSA-N

Diminazene (INN; also known as diminazen) is an anti-infective medication for animals that is sold under a variety of brand names. It is effective against certain protozoa such as Babesia, Trypanosoma, and Cytauxzoon. The drug may also be effective against certain bacteria including Brucella and Streptococcus.[1][2]

Chemically it is a di-amidine and it is formulated as its aceturate salt, diminazene aceturate.

The mechanism is not well understood; it probably inhibits DNA replication,[1] but also has affinity to RNA.

  1. ^ a b Peregrine AS, Mamman M (September 1993). "Pharmacology of diminazene: a review". Acta Tropica. 54 (3–4): 185–203. doi:10.1016/0001-706X(93)90092-P. PMID 7902657.
  2. ^ Mungube EO, Vitouley HS, Allegye-Cudjoe E, Diall O, Boucoum Z, Diarra B, et al. (August 2012). "Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali". Parasites & Vectors. 5: 155. doi:10.1186/1756-3305-5-155. PMC 3432589. PMID 22852796.

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Diminazene

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Diminazene (INN; also known as diminazen) is an anti-infective medication for animals that is sold under a variety of brand names. It is effective against...

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Trypanocidal agent

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Examples include: Aminoquinuride benzonidazole blasticidin S DAPI diminazene diminazene aceturate eflornithine ethidium isometamidium chloride lonidamine...

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Amidine

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amidine is formamidine, HC(=NH)NH2. Examples of amidines include: DBU diminazene benzamidine Pentamidine Paranyline A common route to primary amidines...

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Trypanosoma congolense

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permanent loss of function in this area for the tested trypanocides, diminazene aceturate, isometamidium chloride, and homidium chloride. "Trypanosoma...

Word Count : 397

Isometamidium chloride

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of a single ethidium bromide like subunit linked to a fragment of the diminazene molecule.[citation needed] The Gibe River Valley in southwest Ethiopia...

Word Count : 223

Trypanosoma vivax

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Isometamidium and diminazene are not thought to be in the same trypanocide class.) Resistance to both is widespread in both West and East Africa. Diminazene resistance...

Word Count : 700

Ethidium bromide

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(April 1997). "Long-term occurrence of Trypanosoma congolense resistant to diminazene, isometamidium and homidium in cattle at Ghibe, Ethiopia". Acta Tropica...

Word Count : 1949

Melarsoprol

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drama House MD. Drug resistance evolution is encouraged by the use of diminazene for nagana. "Our Formulary". Infectious Diseases Laboratories. CDC. 22...

Word Count : 1744

Trypanosoma evansi

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ineffective. Trypanosoma evansi trypanocide resistance is widespread. Diminazene aceturate is often ineffective for bovine, equine, porcine, and elephant...

Word Count : 2638

Parasitic flies of domestic animals

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Tuntasuvana, D. et al. (2003) Chemotherapy of surra in horses and mules with diminazene aceturate. Veterinary Parasitology, 110: 227-233. http://doi.org/10...

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Trypanosoma brucei

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suitable for clinical use. Animal trypanosomiasis is treated with six drugs: diminazene aceturate, homidium (homidium bromide and homidium chloride), isometamidium...

Word Count : 12253

Miltefosine

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showed that it is not as potent as other drugs, such as chlorpromazine and diminazene aceturate (Berenil). In 2013, there were reports of failure of miltefosine...

Word Count : 3583

Rangelia

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This disease may be transmitted by blood transfusion. Treatment with diminazene aceturate has been shown to be effective. Amblyomma aureolatum Crab-eating...

Word Count : 420
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