Dicoumarol (INN) or dicumarol (USAN) is a naturally occurring anticoagulant drug that depletes stores of vitamin K (similar to warfarin, a drug that dicoumarol inspired). It is also used in biochemical experiments as an inhibitor of reductases.
Dicoumarol is a natural chemical substance of combined plant and fungal origin. It is a derivative of coumarin, a bitter-tasting but sweet-smelling substance made by plants that does not itself affect coagulation, but which is (classically) transformed in mouldy feeds or silages by a number of species of fungi, into active dicoumarol. Dicoumarol does affect coagulation, and was discovered in mouldy wet sweet-clover hay, as the cause of a naturally occurring bleeding disease in cattle.[1] See warfarin for a more detailed discovery history.
Identified in 1940, dicoumarol became the prototype of the 4-hydroxycoumarin anticoagulant drug class. Dicoumarol itself, for a short time, was employed as a medicinal anticoagulant drug, but since the mid-1950s has been replaced by its simpler derivative warfarin, and other 4-hydroxycoumarin drugs.
It is given orally, and it acts within two days.
^Kresge N, Simoni RD, Hill RL (February 2005). "Hemorrhagic sweet clover disease, dicumarol, and warfarin: the work of Karl Paul Link". Journal of Biological Chemistry. 280 (8): e6–e7. doi:10.1016/S0021-9258(19)62862-0.
Dicoumarol (INN) or dicumarol (USAN) is a naturally occurring anticoagulant drug that depletes stores of vitamin K (similar to warfarin, a drug that dicoumarol...
Fusarium, and Mucor) can convert coumarin into dicoumarol, a toxic anticoagulant. Consequently, dicoumarol may be found in decaying sweet-clover, and was...
formaldehyde) into the actual anticoagulant dicoumarol, a fermentation product and mycotoxin. Dicoumarol was responsible for the bleeding disease known...
native plant species. Sweet clover contains coumarin that converts to dicoumarol, which is a powerful anticoagulant toxin, when the plant becomes moldy...
3'-methylenebis-(4-hydroxycoumarin), which they later named dicoumarol. They confirmed their results by synthesizing dicoumarol and proving in 1940 that it was identical...
synthesised and tested it; it turned out to be dicoumarol (3,3'-methylenebis-(4 hydroxycoumarin)). Dicoumarol was subjected to clinical trials in Wisconsin...
synthesis of a number of synthetic anticoagulant pharmaceuticals similar to dicoumarol. 4-hydroxycoumarins are a type of vitamin K antagonist. They block the...
4-hydroxycoumarins. Warfarin (Coumadin) Coumatetralyl Phenprocoumon Acenocoumarol Dicoumarol Tioclomarol Brodifacoum Another group of VKAs are 1,3-indandione derivatives...
codes not present in this list, which follows the WHO version. B01AA01 Dicoumarol B01AA02 Phenindione B01AA03 Warfarin B01AA04 Phenprocoumon B01AA07 Acenocoumarol...
anticoagulant, with a similar mode of action to its historical predecessors dicoumarol and warfarin. However, due to very high potency and long duration of action...
for various 4-hydroxybenzopyrone-based molecules which occur naturally dicoumarol and are made synthetically warfarin and function as anticoagulants. full...
affected by salinity. It has been used in herbal medicine. It includes dicoumarol, which is an anticoagulant. It also has a high sugar content. White sweetclover...
"Neurophysiology, in particular the physiological basis of electroencephalography" "Dicoumarol and related compounds" “for their discovery of the ability of poliomyelitis...
especially stilboestrol (diethylstilbestrol, DES) and their effects." "Dicoumarol and related compounds" “for their discoveries in the chemistry of the...
substance causing the internal bleeding. It took them 6 years to discover dicoumarol, the causing agent. They patented the right for the substance and in 1945...
Global Information
(what is this?) (verify)