The Darzens reaction (also known as the Darzens condensation or glycidic ester condensation) is the chemical reaction of a ketone or aldehyde with an α-haloester in the presence of a base to form an α,β-epoxy ester, also called a "glycidic ester".[1][2][3] This reaction was discovered by the organic chemist Auguste Georges Darzens in 1904.[4][5][6]
^Newman, M. S; Magerlein, B. J (1949). "The Darzens Glycidic Ester Condensation". Organic Reactions. 5 (10): 413–440. doi:10.1002/0471264180.or005.10.
^Jie Jack Li (2006). "Darzens glycidic ester condensation". Name Reactions (3rd. expanded ed.). Springer-Verlag. pp. 183–184. doi:10.1007/3-540-30031-7. ISBN 978-3-540-30030-4.
^Ballester, Manuel (April 1955). "Mechanisms of The Darzens and Related Condensations Manuel Ballester". Chemical Reviews. 55 (2): 283–300. doi:10.1021/cr50002a002.
^Darzens, G. (1904). "Method generale de synthese des aldehyde a l'aide des acides glycidique substitues". Compt. Rend. (in French). 139: 1214.
^Darzens, G. (1905). "Methode generale de synthese des d'esters glycidiques αβ substitues et de cetones". Compt. Rend. (in French). 141: 766.
^Darzens, G. (1906). "Condensation glycidique des aldehydes avec l'ether alpha-chloropropionique". Compt. Rend. (in French). 142: 214.
The Darzensreaction (also known as the Darzens condensation or glycidic ester condensation) is the chemical reaction of a ketone or aldehyde with an...
corresponding hydrochloride or hydrobromide salt. The reaction is named after its creator, Auguste Georges Darzens, who first reported it in 1911. The addition...
Such reactions can form the basis of more complicated processes, for example epoxide formation is one of the key steps in the Darzensreaction. Compounds...
intramolecular epoxide formation reaction is one of the key steps in the Darzensreaction. In the Johnson–Corey–Chaykovsky reaction epoxides are generated from...
dihydronaphthalene (dialin). In a classic named reaction called the Darzens tetralin synthesis, named for Auguste Georges Darzens (1926), derivatives can be prepared...
Dehydrogenation of 2-Phenylethanol over silver or gold catalysts. Darzensreaction between benzaldehyde and chloroacetate esters. Wacker oxidation of...
discovered the Darzensreaction, a chemical reaction also known as the Darzens condensation and Darzens glycidic ester condensation. Other reactions named after...
functionality is critical for most existing methods. The asymmetric Darzensreaction between aldehydes and (alpha)-haloesters is an effective method for...
ester of monochloroacetic acid in the presence of a base, in a reaction known as the Darzens condensation. Long-term, high-dose studies in rats have demonstrated...
Douglas Boatman, Mitsuru Shindo, Chase C. Smith, Soekchan Kim, et al.; J. Am. Chem. Soc. 1994, 116(4), 1597-1598. (doi:10.1021/ja00083a066) Darzensreaction...
used to promote condensation reactions of carbonyl compounds via the Dieckmann condensation, Stobbe condensation, Darzens condensation, and Claisen condensation...
receptor antagonist and antagonist of the imidazoline receptor. The Darzensreaction between 2-fluorobenzaldehyde [57848-46-1] (1) and Ethyl 2-bromobutyrate...
SOCl2 with pyridine was called the Darzens halogenation, but this name is rarely used by modern chemists. Reactions with an excess of alcohol produce sulfite...
halogenating agents combine with base to effect the conversion. In the "Darzens halogenation", thionyl chloride (SOCl 2) with pyridine converts less reactive...
Galton Darwin Darwin point, Darwinism – Charles Darwin Darzens condensation – Auguste Georges Darzens Davies–Bouldin index (DBI) – David L. Davies and Donald...
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