IPO13 information

IPO13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X19, 2XWU, 3ZJY
Identifiers
Aliases	IPO13, IMP13, KAP13, LGL2, RANBP13, importin 13
External IDs	OMIM: 610411; MGI: 2385205; HomoloGene: 40968; GeneCards: IPO13; OMA:IPO13 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	43,968,022 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	117,772,196 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; gastrocnemius muscle; ; apex of heart; ; muscle of thigh; ; putamen; ; corpus callosum; ; right hemisphere of cerebellum; ; inferior ganglion of vagus nerve; ; right frontal lobe; ; external globus pallidus;
	Top expressed in
	muscle of thigh; ; neural layer of retina; ; skeletal muscle tissue; ; knee joint; ; medial head of gastrocnemius muscle; ; vastus lateralis muscle; ; extraocular muscle; ; temporal muscle; ; triceps brachii muscle; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; nuclear localization sequence binding;
Cellular component	nucleus; nuclear membrane; cytoplasm;
Biological process	protein import into nucleus; protein transport; intracellular protein transport;
	Sources:Amigo / QuickGO
Orthologs
	9670
	230673
	ENSG00000117408
	ENSMUSG00000033365
	O94829
	Q8K0C1
	NM_014652
	NM_146152
	NP_055467
	NP_666264
	Wikidata
View/Edit Human	View/Edit Mouse

Importin-13 is a protein encoded by the IPO13 gene in humans.^[5]^[6]^[7] Importin-13 is a member of the importin-β family of nuclear transport receptors (NTRs) and was first identified as a transport receptor in 2000.^[8] According to PSI-blast based secondary structure PREDiction (PSIPRED), importin-13 contains 38 α-helices.^[9] Importin-13 accommodates a range of cargoes due to its flexible superhelical structure and a cargo binding and release system that is distinct from other importin-like transport receptors.^[8]^[10] IPO13 is broadly expressed in a variety of tissues in the human body, including the heart,^[11] cornea,^[11] fetal lung,^[11] brain,^[11] endometrial carcinoma,^[11] and testes.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117408 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033365 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, et al. (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–286. doi:10.1093/dnares/5.5.277. PMID 9872452.
^ Mingot JM, Kostka S, Kraft R, Hartmann E, Görlich D (July 2001). "Importin 13: a novel mediator of nuclear import and export". The EMBO Journal. 20 (14): 3685–3694. doi:10.1093/emboj/20.14.3685. PMC 125545. PMID 11447110.
^ "Entrez Gene: IPO13 importin 13".
^ ^a ^b Baade I, Spillner C, Schmitt K, Valerius O, Kehlenbach RH (July 2018). "Extensive Identification and In-depth Validation of Importin 13 Cargoes". Molecular & Cellular Proteomics. 17 (7): 1337–1353. doi:10.1074/mcp.ra118.000623. PMC 6030721. PMID 29666159.
^ Walker P, Doenecke D, Kahle J (April 2009). "Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers". The Journal of Biological Chemistry. 284 (17): 11652–11662. doi:10.1074/jbc.m806820200. PMC 2670169. PMID 19218565.
^ ^a ^b Fatima S, Wagstaff KM, Lieu KG, Davies RG, Tanaka SS, Yamaguchi YL, et al. (March 2017). "Interactome of the inhibitory isoform of the nuclear transporter Importin 13". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1864 (3): 546–561. doi:10.1016/j.bbamcr.2016.12.017. PMID 27993670.
^ ^a ^b ^c ^d ^e Zohud BA, Guo P, Zohud BA, Li F, Hao JJ, Shan X, et al. (October 2020). "Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation". Cell Death & Disease. 11 (10): 879. doi:10.1038/s41419-020-03101-9. PMC 7575581. PMID 33082305.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117408 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033365 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872452-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, et al. (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–286. doi:10.1093/dnares/5.5.277. PMID 9872452.

[pmid11447110-6] Mingot JM, Kostka S, Kraft R, Hartmann E, Görlich D (July 2001). "Importin 13: a novel mediator of nuclear import and export". The EMBO Journal. 20 (14): 3685–3694. doi:10.1093/emboj/20.14.3685. PMC 125545. PMID 11447110.

[entrez-7] "Entrez Gene: IPO13 importin 13".

[Baade_2018-8] Baade I, Spillner C, Schmitt K, Valerius O, Kehlenbach RH (July 2018). "Extensive Identification and In-depth Validation of Importin 13 Cargoes". Molecular & Cellular Proteomics. 17 (7): 1337–1353. doi:10.1074/mcp.ra118.000623. PMC 6030721. PMID 29666159.

[Walker_2009-9] Walker P, Doenecke D, Kahle J (April 2009). "Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers". The Journal of Biological Chemistry. 284 (17): 11652–11662. doi:10.1074/jbc.m806820200. PMC 2670169. PMID 19218565.

[Fatima_2017-10] Fatima S, Wagstaff KM, Lieu KG, Davies RG, Tanaka SS, Yamaguchi YL, et al. (March 2017). "Interactome of the inhibitory isoform of the nuclear transporter Importin 13". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1864 (3): 546–561. doi:10.1016/j.bbamcr.2016.12.017. PMID 27993670.

[Zohud_2020-11] Zohud BA, Guo P, Zohud BA, Li F, Hao JJ, Shan X, et al. (October 2020). "Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation". Cell Death & Disease. 11 (10): 879. doi:10.1038/s41419-020-03101-9. PMC 7575581. PMID 33082305.

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