Folding of DNA to create two- and three-dimensional shapes at the nanoscale
DNA origami object from viral DNA visualized by electron tomography.[1] The map is at the top and atomic model of the DNA colored below. (Deposited in EMDB EMD-2210)
DNA origami is the nanoscale folding of DNA to create arbitrary two- and three-dimensional shapes at the nanoscale. The specificity of the interactions between complementary base pairs make DNA a useful construction material, through design of its base sequences.[2] DNA is a well-understood material that is suitable for creating scaffolds that hold other molecules in place or to create structures all on its own.
DNA origami was the cover story of Nature on March 16, 2006.[3] Since then, DNA origami has progressed past an art form and has found a number of applications from drug delivery systems to uses as circuitry in plasmonic devices; however, most commercial applications remain in a concept or testing phase.[4]
^Bai, Xiao-chen; Martin, Thomas G.; Scheres, Sjors H. W.; Dietz, Hendrik (2012-12-04). "Cryo-EM structure of a 3D DNA-origami object". Proceedings of the National Academy of Sciences. 109 (49): 20012–20017. doi:10.1073/pnas.1215713109. ISSN 0027-8424. PMC 3523823. PMID 23169645.
^Zadegan, R.M.; Norton, M.L. (2012). "Structural DNA Nanotechnology: From Design to Applications". Int. J. Mol. Sci. 13 (6): 7149–7162. doi:10.3390/ijms13067149. PMC 3397516. PMID 22837684.
^Rothemund, Paul W. K. (2006). "Folding DNA to create nanoscale shapes and patterns". Nature. 440 (7082): 297–302. Bibcode:2006Natur.440..297R. doi:10.1038/nature04586. PMID 16541064. S2CID 4316391.
^Sanderson, Katharine (2010). "Bioengineering: What to make with DNA origami". Nature. 464 (7286): 158–159. doi:10.1038/464158a. PMID 20220817.
DNAorigami is the nanoscale folding of DNA to create arbitrary two- and three-dimensional shapes at the nanoscale. The specificity of the interactions...
synthesize. DNAorigami was the cover story of Nature on March 15, 2006. Rothemund's research demonstrating two-dimensional DNAorigami structures was...
the RNA occurs in living cells under natural conditions. RNA origami is represented as a DNA gene, which within cells can be transcribed into RNA by RNA...
Rothemund made a breakthrough in DNA nanotechnology, developing the DNAorigami. His DNAorigami took a long, single-stranded DNA molecule (referred to as the...
The discipline of origami or paper folding has received a considerable amount of mathematical study. Fields of interest include a given paper model's...
George Church lab at Harvard University. His fields of expertise include DNAorigami, synthetic biology, and biomimetics. He taught life sciences at Bar-Ilan...
mimic osteoclast resorption pits. Researchers have successfully used DNAorigami-based nanobots capable of carrying out logic functions to achieve targeted...
2006, Paul Rothemund first demonstrated the DNAorigami technique for easily and robustly creating folded DNA structures of arbitrary shape. This method...
concentration to be used. A novel use of DNA ligase can be seen in the field of nano chemistry, specifically in DNAorigami. DNA based self-assembly principles...
of DNAorigami mechanisms, Proceedings of the National Academy of Sciences, 2015 Archived 2017-08-04 at the Wayback Machine McCarthy, C, DNAOrigami Mechanisms...
shape to bind a desired molecule. The most innovative processes use DNAorigami for this, creating sequences that fold in a predictable structure that...
largest DNA circuit, which included over seventy DNA molecules. Qian has also created complex DNAorigami. She created two-dimensional images from DNA origami...
algorithms. Potential infrastructure for future technologies includes DNAorigami on photolithography and quantum antennae for transferring information...
Germany) is a German physicist known for his contributions in the field of DNAorigami. He is a full-professor for biophysics at the Technical University of...
nanotechnology and DNAorigami, (although both are important to the field of nucleic acid–guided programmable materials. With DNAorigami, such structures...
predefined shapes. Note that conceptually, DNA single stranded origami is more related to RNA origami than DNAorigami. Though RNA nanotechnology is still a...
self-assembled DNA nanostructures such as Sierpinski triangles or arbitrary nanoshapes obtained using the DNAorigami technique, and DNA nanomachines such as DNA-based...
included fluorescent tracking of cell surface receptors, decorating DNAorigami, and acting as a pointer to identify specific regions for cryo-electron...
the design of DNAorigami, because the sequence is predetermined by the choice of scaffold strand. Software specifically for DNAorigami design has been...
"Student creates Script Ohio out of DNA". Sunny 95. March 15, 2015. Retrieved April 28, 2018. "Script Ohio from DNAOrigami Dubbed "Officially Amazing" by...
artificial light harvesting systems, virus templated assemblies and DNAorigami have also been employed for light harvesting applications. Reversible...
reactive DNA hairpins on DNAorigami surfaces are some examples that mark the progress in the field of logic gate-based DNA computing. Nanorobots have...
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