DDX3Y information

DDX3Y
Identifiers
Aliases	DDX3Y, DBY, DEAD-box helicase 3, Y-linked, DEAD-box helicase 3 Y-linked
External IDs	OMIM: 400010 MGI: 1349406 HomoloGene: 55839 GeneCards: DDX3Y
Gene location (Human) Chr. Y chromosome (human)[1] Band Yq11.221 Start 12,904,108 bp[1] End 12,920,478 bp[1]
Gene location (Mouse) Chr. Y chromosome (mouse)[2] Band Y|Ypter Start 1,260,771 bp[2] End 1,286,629 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm endothelial cell right lung caput epididymis seminal vesicula corpus epididymis trabecular bone rectum prostate cerebellar vermis Top expressed in median eminence dorsomedial hypothalamic nucleus mammillary body habenula arcuate nucleus subcutaneous adipose tissue left lung lobe retinal pigment epithelium dorsal tegmental nucleus lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding hydrolase activity ATP binding helicase activity RNA binding nucleic acid binding Cellular component cytoplasmic ribonucleoprotein granule membrane nucleus cytoplasm cytosol nucleolus Biological process translational initiation regulation of gene expression RNA secondary structure unwinding chromosome segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8653 26900 Ensembl ENSG00000067048 ENSMUSG00000069045 UniProt O15523 Q62095 RefSeq (mRNA) NM_001122665 NM_001302552 NM_004660 NM_001324195 NM_012008 RefSeq (protein) NP_001116137 NP_001289481 NP_001311124 NP_004651 NP_036138 Location (UCSC) Chr Y: 12.9 – 12.92 Mb Chr Y: 1.26 – 1.29 Mb PubMed search [3] [4]
Wikidata
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ATP-dependent RNA helicase DDX3Y is an enzyme that in humans is encoded by the DDX3Y gene.^[5][6]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome (DDX3X). The gene mutation causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Alternative splicing of this gene generates 2 transcripts, which differ only in the length of the 3' UTR.^[6]