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A conservative replacement (also called a conservative mutation or a conservative substitution) is an amino acid replacement in a protein that changes a given amino acid to a different amino acid with similar biochemical properties (e.g. charge, hydrophobicity and size).[1][2]
Conversely, a radical replacement, or radical substitution, is an amino acid replacement that exchanges an initial amino acid by a final amino acid with different physicochemical properties.[1]
^ abZhang, Jianzhi (2000-01-01). "Rates of Conservative and Radical Nonsynonymous Nucleotide Substitutions in Mammalian Nuclear Genes". Journal of Molecular Evolution. 50 (1): 56–68. Bibcode:2000JMolE..50...56Z. CiteSeerX 10.1.1.584.896. doi:10.1007/s002399910007. ISSN 0022-2844. PMID 10654260. S2CID 15248867.
^Dagan, Tal; Talmor, Yael; Graur, Dan (2002-07-01). "Ratios of Radical to Conservative Amino Acid Replacement are Affected by Mutational and Compositional Factors and May Not Be Indicative of Positive Darwinian Selection". Molecular Biology and Evolution. 19 (7): 1022–1025. doi:10.1093/oxfordjournals.molbev.a004161. ISSN 0737-4038. PMID 12082122.
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