For bacteria with a polysaccharide coating, like Haemophilus influenzae type b, the best way to prevent infection is to use a conjugate vaccine.[1]
A conjugate vaccine is a type of subunit vaccine which combines a weak antigen with a strong antigen as a carrier so that the immune system has a stronger response to the weak antigen.
Vaccines are used to prevent diseases by invoking an immune response to an antigen, part of a bacterium or virus that the immune system recognizes.[2] This is usually accomplished with an attenuated or dead version of a pathogenic bacterium or virus in the vaccine, so that the immune system can recognize the antigen later in life.[2]
Most vaccines contain a single antigen that the body will recognize. However, the antigen of some pathogens does not elicit a strong response from the immune system, so a vaccination against this weak antigen would not protect the person later in life. In this case, a conjugate vaccine is used in order to invoke an immune system response against the weak antigen. In a conjugate vaccine, the weak antigen is covalently attached to a strong antigen, thereby eliciting a stronger immunological response to the weak antigen. Most commonly, the weak antigen is a polysaccharide that is attached to strong protein antigen. However, peptide/protein and protein/protein conjugates have also been developed.[3]
^"Immunization: You Call the Shots". www2.cdc.gov. Archived from the original on 2010-06-03. Retrieved 2018-11-29.
^ ab"Understanding How Vaccines Work | CDC". www.cdc.gov. 2018-10-18. Archived from the original on 2020-01-02. Retrieved 2018-11-29.
A conjugatevaccine is a type of subunit vaccine which combines a weak antigen with a strong antigen as a carrier so that the immune system has a stronger...
Pneumococcal conjugatevaccine is a pneumococcal vaccine made with the conjugatevaccine method and used to protect infants, young children, and adults...
and thirty with the meningococcal A conjugatevaccine are ongoing. In Canada and the United States the vaccines effective against four types of meningococcus...
hepatitis B vaccine, among others. All Hib vaccines that are currently used are conjugatevaccine. An initial Hib vaccine consisting of plain (unconjugated) type...
and sepsis. There are two types of pneumococcal vaccines: conjugatevaccines and polysaccharide vaccines. They are given by injection either into a muscle...
Typhoid vaccines are vaccines that prevent typhoid fever. Several types are widely available: typhoid conjugatevaccine (TCV), Ty21a (a live oral vaccine) and...
conjugatevaccine ("Typbar-TCV") is another Vi-based conjugatevaccine, in this case linked to Tetanus toxoid. It has been approved. Typhoid vaccine Milligan...
A hexavalent vaccine, or 6-in-1 vaccine, is a combination vaccine with six individual vaccinesconjugated into one, intended to protect people from multiple...
licensing of a protein conjugate heptavalent vaccine (PCV7) beginning in February 2000. In the United States, pneumococcal vaccine, polyvalent is indicated...
the polysacchide with a toxoid increases the efficacy. A conjugatevaccine is a type of vaccine which combines a weak antigen with a strong antigen as a...
IgG antibodies, conjugatevaccines show potential as an alternative method of treating drug use disorders. The list of nicotine vaccines that have been...
one or more of the additional vaccines: inactivated polio virus vaccine (IPV), Haemophilus influenzae type b conjugate, Hepatitis B, with the availability...
The DPT vaccine or DTP vaccine is a class of combination vaccines against three infectious diseases in humans: diphtheria, pertussis (whooping cough)...
areas. Although conjugatevaccines are the preferred meningococcal vaccine in adults 55 years of age or younger, polysaccharide vaccines are an acceptable...
injectable polio vaccine, an adult vaccine against Japanese Encephalitis and Pneumococcal ConjugateVaccine.[citation needed] Vaccines against rotavirus...
tb00196.x. ISSN 0928-8244. PMID 8745007. "Polysaccharide Protein ConjugateVaccines". www.globalhealthprimer.emory.edu. Archived from the original on...
between bacteria Conjugatevaccine, in immunology Conjugation (biochemistry), covalently linking a biomolecule with another molecule Conjugate (acid-base theory)...
the pneumococcal conjugatevaccine and rotavirus vaccine, and in pregnant women, the influenza and respiratory syncytial virus vaccines. Since the global...
Administration (FDA). 24 May 2019. Retrieved 6 May 2020. "Haemophilus B ConjugateVaccine". U.S. Food and Drug Administration (FDA). 22 July 2017. Retrieved...
hepatitis A 1998 – First vaccine for Lyme disease 1998 – First vaccine for rotavirus 2000 – First pneumococcal conjugatevaccine approved in the U.S. (PCV7...
Nohynek H, Riley ID, Makela H (October 2009). "Pneumococcal conjugatevaccines for preventing vaccine-type invasive pneumococcal disease and X-ray defined pneumonia...
recently been elucidated. CRM197 is widely used as a carrier protein for conjugatevaccines. A potential advantage of CRM197 over toxoided proteins is that, because...
the U.S. The first conjugate vaccine was licensed in 2005, the second in 2010. Conjugatevaccines are the preferred vaccine for people 2 through 55 years...
The HVP vaccine contains 120 micrograms of the L1 capsid proteins from four types of human papillomavirus. The pneumococcal conjugatevaccine contains...
Global Information