Protein playing a major role in the formation of coated vesicles
Clathrin heavy N-terminal propeller repeat
Clathrin terminal domain
Identifiers
Symbol
Clathrin_propel
Pfam
PF01394
Pfam clan
CL0020
InterPro
IPR022365
SCOP2
1bpo / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Clathrin heavy-chain linker
clathrin heavy chain proximal repeat (linker)
Identifiers
Symbol
Clathrin-link
Pfam
PF09268
Pfam clan
CL0020
InterPro
IPR015348
SCOP2
1b89 / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
CHCR/VPS 7-fold repeat
Identifiers
Symbol
Clathrin_propel
Pfam
PF00637
Pfam clan
CL0020
InterPro
IPR000547
SMART
SM00299
PROSITE
PS50236
CATH
1b89
SCOP2
1b89 / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Clathrin light chain
Identifiers
Symbol
Clathrin_lg_ch
Pfam
PF01086
InterPro
IPR000996
PROSITE
PDOC00196
SCOP2
3iyv / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Clathrin is a protein that plays a major role in the formation of coated vesicles. Clathrin was first isolated by Barbara Pearse in 1976.[1] It forms a triskelion shape composed of three clathrin heavy chains and three light chains. When the triskelia interact they form a polyhedral lattice that surrounds the vesicle. The protein's name refers to this lattice structure, deriving from Latin clathri meaning lattice.[2] Barbara Pearse named the protein clathrin at the suggestion of Graeme Mitchison, selecting it from three possible options.[3] Coat-proteins, like clathrin, are used to build small vesicles in order to transport molecules within cells. The endocytosis and exocytosis of vesicles allows cells to communicate, to transfer nutrients, to import signaling receptors, to mediate an immune response after sampling the extracellular world, and to clean up the cell debris left by tissue inflammation. The endocytic pathway can be hijacked by viruses and other pathogens in order to gain entry to the cell during infection.[4]
^Pearse BM (April 1976). "Clathrin: a unique protein associated with intracellular transfer of membrane by coated vesicles". Proceedings of the National Academy of Sciences of the United States of America. 73 (4): 1255–1259. Bibcode:1976PNAS...73.1255P. doi:10.1073/pnas.73.4.1255. PMC 430241. PMID 1063406.
^"clathrate, adjective". Merriam-Webster. Retrieved 29 November 2023.
^Pearse BM (September 1987). "Clathrin and coated vesicles". EMBO J. 6 (9): 2507–12. doi:10.1002/j.1460-2075.1987.tb02536.x. PMC 553666. PMID 2890519.
^"InterPro". Archived from the original on 2016-01-16. Retrieved 2015-10-07.
Clathrin is a protein that plays a major role in the formation of coated vesicles. Clathrin was first isolated by Barbara Pearse in 1976. It forms a triskelion...
cytosolic protein clathrin. Clathrin-coated vesicles (CCVs) are found in virtually all cells and form domains of the plasma membrane termed clathrin-coated pits...
Clathrin adaptor proteins, also known as adaptins, are vesicular transport adaptor proteins associated with clathrin. These proteins are synthesized in...
multimeric protein that works on the cell membrane to internalize cargo in clathrin-mediated endocytosis. It is a stable complex of four adaptins which give...
particles to the lysosome. The clathrin-coated pit invaginates into the cytosol and forms a clathrin-coated vesicle. The clathrin proteins will then dissociate...
The clathrin coats are lost almost immediately, and the membrane is subsequently recycled to the cell surface. Macropinocytosis is a clathrin-independent...
Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene. PICALM has been...
continuously between the plasma membrane and endosomal compartments in a clathrin-dependent manner. The mannose receptor is a type I transmembrane protein...
attachment of the viral envelope protein E to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the positive-stranded RNA virus...
in clathrin-mediated endocytosis of synaptic vesicles. It is capable of simultaneously binding both membrane lipids (via an ANTH domain) and clathrin and...
Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene. Clathrin is a major protein component of the cytoplasmic face of intracellular...
eukaryotes there are several conserved motifs such as the clathrin-binding motifs which bind clathrin heavy chain, these motifs flank a cluster of up to eight...
Frances Brodsky is an American cell biologist. She is known for her work on clathrin and its role in the function of the immune system. She is a professor of...
attachment of the viral G glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus...
membrane. More recently, however, productive infection by pH-independent, clathrin-mediated endocytosis of HIV-1 has also been reported and was recently suggested...
via clathrin-coated pits. Attachment to αV integrin stimulates cell signaling and thus induces actin polymerization, which facilitates clathrin-mediated...
located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic...
attachment of the viral envelope protein E to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the positive-strand RNA virus...
point group of triskelion-shaped molecules is C3h. The endocytic protein, clathrin, is triskelion-shaped, as well as the Ediacaran organism Tribrachidium...
"Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP". Genomics. 30 (1): 94–7...
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