de Duve lecturing on the origin of the eukaryotic cell in 2012
Born
Christian René Marie Joseph de Duve
(1917-10-02)2 October 1917
Thames Ditton, Surrey, England
Died
4 May 2013(2013-05-04) (aged 95)
Grez-Doiceau, Belgium
Nationality
Belgian
Alma mater
Our Lady College, Antwerp
Catholic University of Leuven
Known for
Cell organelles
Children
4, including Thierry
Awards
See list
Francqui Prize (1960)
Gairdner Foundation International Award (1967)
Dr H.P. Heineken Prize for Biochemistry and Biophysics (1973)
Nobel Prize for Physiology or Medicine (1974)
ForMemRS (1988)[1]
E.B. Wilson Medal (1989)
Scientific career
Fields
Medicine
Endocrinology
Biochemistry
Cell biology
Institutions
Catholic University of Leuven
University of Louvain
Rockefeller University
Washington University School of Medicine
Christian René Marie Joseph, Viscount de Duve (2 October 1917 – 4 May 2013) was a Nobel Prize-winning Belgian cytologist and biochemist.[2] He made serendipitous discoveries of two cell organelles, peroxisome and lysosome, for which he shared the Nobel Prize in Physiology or Medicine in 1974 with Albert Claude and George E. Palade ("for their discoveries concerning the structural and functional organization of the cell").[3] In addition to peroxisome and lysosome, he invented scientific names such as autophagy, endocytosis, and exocytosis in a single occasion.[4][5][6][7][8]
The son of Belgian refugees during the First World War, de Duve was born in Thames Ditton, Surrey, England.[9] His family returned to Belgium in 1920. He was educated by the Jesuits at Our Lady College, Antwerp, and studied medicine at the Catholic University of Leuven. Upon earning his MD in 1941, he joined research in chemistry, working on insulin and its role in diabetes mellitus. His thesis earned him the highest university degree agrégation de l'enseignement supérieur (equivalent to PhD) in 1945.[10]
With his work on the purification of penicillin, he obtained an MSc degree in 1946. He went for further training under (later Nobel Prize winners) Hugo Theorell at the Karolinska Institutet in Stockholm, and Carl and Gerti Cori at the Washington University in St. Louis. He joined the faculty of medicine at Leuven in 1947. In 1960 he was invited to the Rockfeller Institute (now Rockefeller University). With mutual arrangement with Leuven, he became professor in both universities from 1962, dividing his time between Leuven and New York. In 1974, the same year he received his Nobel Prize, he founded the ICP, which would later be renamed the de Duve Institute.[11] He became emeritus professor of the University of Louvain in 1985, and of Rockefeller in 1988.[12]
De Duve was granted the rank of Viscount in 1989 by King Baudouin of Belgium. He was also a recipient of Francqui Prize, Gairdner Foundation International Award, Heineken Prize, and E.B. Wilson Medal. In 1974 he founded the International Institute of Cellular and Molecular Pathology in Brussels, eventually renamed the de Duve Institute in 2005. He was the founding President of the L'Oréal-UNESCO Awards for Women in Science.[13] He died by legal euthanasia after long suffering from cancer and atrial fibrillation.[14][15]
^"Fellowship of the Royal Society 1660–2015". London: Royal Society. Archived from the original on 15 October 2015.
^Blobel, Günter (2013). "Christian de Duve (1917–2013) Biologist who won a Nobel prize for insights into cell structure". Nature. 498 (7454): 300. Bibcode:2013Natur.498..300B. doi:10.1038/498300a. PMID 23783621.
^"The Nobel Prize in Physiology or Medicine 1974". Nobel Foundation. Retrieved 31 December 2014.
^Christian de Duve on Nobelprize.org
^de Duve, C. "A rather ordinary person". Web of Stories. Retrieved 4 May 2017.
^Free to view video interview with Christian de Duve provided by the Vega Science Trust
^Biography, The Daily Telegraph. Retrieved 11 February 2018.
^Retrospective: Christian de Duve, 1917–2013 Archived 15 May 2019 at the Wayback Machine, asbmb.org. Retrieved 11 February 2018.
^Denise Gellene (6 May 2013). "Christian de Duve, 95, Dies; Nobel-Winning Biochemist". The New York Times. Retrieved 18 November 2013.
^de Duve, Christian (2004). "My love affair with insulin". Journal of Biological Chemistry. 279 (21): 21679–21688. doi:10.1074/jbc.X400002200. PMID 15023999.
^"Institut de Duve". deduveinstitute.be. Retrieved 17 September 2022.
^Tricot, JP (2006). "Nobel prize winner Christian de Duve. From insulin to lysosomes". Hormones. 5 (2): 151–5. doi:10.14310/horm.2002.11179. PMID 16807228.
^UNESCO Media Services (17 May 2013). "The Director-General Pays Tribute to the Memory of Professor Christian de Duve". UNESCO. Retrieved 30 June 2013.
^Cite error: The named reference :0 was invoked but never defined (see the help page).
^Cite error: The named reference :1 was invoked but never defined (see the help page).
Christian René Marie Joseph, Viscount deDuve (2 October 1917 – 4 May 2013) was a Nobel Prize-winning Belgian cytologist and biochemist. He made serendipitous...
smaller ones. They were discovered and named by Belgian biologist ChristiandeDuve, who eventually received the Nobel Prize in Physiology or Medicine...
include: ChristiandeDuve (1917–2013), Nobel Prize-winning Belgian cytologist and biochemist Freimut Duve (1936–2020), German politician Karen Duve (born...
Thierry deDuve (born 1944) is a Belgian professor of modern art theory and contemporary art theory, and both teaches and publishes books in the field...
microbodies in liver cells. Then in 1965, ChristiandeDuve and coworkers isolated microbodies from the liver of a rat. DeDuve also believed that the name Microbody...
present usage, the term autophagy was coined by Belgian biochemist ChristiandeDuve in 1963 based on his discovery of the functions of lysosome. The identification...
who shared the Nobel Prize in Physiology or Medicine in 1974 with ChristiandeDuve and George Emil Palade. His elementary education started in a comprehensive...
physician and politician, 44th Governor of Indiana (b. 1918) 2013 – ChristiandeDuve, English-Belgian cytologist and biochemist, Nobel Prize laureate (b...
Nobel Prize in Physiology and Medicine along with Albert Claude and ChristiandeDuve. The prize was granted for his innovations in electron microscopy...
from the original on 16 July 2020. Gellene, Denise (May 6, 2013). "ChristiandeDuve, 95, Dies; Nobel-Winning Biochemist". The New York Times. Archived...
Belgian Society of Biochemistry and Molecular Biology. Together with ChristiandeDuve, and others, he wrote a proposal for the statutes which was adopted...
in 1954. They were identified as organelles by ChristiandeDuve and Pierre Baudhuin in 1966. DeDuve and co-workers discovered that peroxisomes contain...
1410/20–1475) Eustace Chapuys, Imperial ambassador to England (1489–1556) ChristiandeDuve, cytologist and biochemist, recipient of the 1974 Nobel Prize for...
"Thioester World", thioesters are possible precursors to life. As ChristiandeDuve explains: It is revealing that thioesters are obligatory intermediates...
Englert, Physics, 2013 Ilya Prigogine, born in Russia, Chemistry, 1977 ChristiandeDuve, born in the United Kingdom, Physiology or Medicine, 1974 Albert Claude...
prizes ChristiandeDuve Albert Claude Miscellaneous Louvain modularity Claroline Orchestre Symphonique des Étudiants de Louvain-la-Neuve 24h vélo de Louvain-la-Neuve...
Ditton. Dominic Raab – former Deputy Prime Minister[citation needed] ChristiandeDuve, Nobel-Prize (1974), born Thames Ditton 1917 Henry Smith – recipient...
Leontief 1974 Martin Ryle; Antony Hewish Paul Flory Albert Claude; ChristiandeDuve; George Emil Palade Eyvind Johnson; Harry Martinson Seán MacBride;...
Bruxelles) together with Christian de Duve (Université catholique de Louvain) in 1974. François Englert (Université libre de Bruxelles) was awarded the Nobel...
Volume 1 by ChristiandeDuve A Guided Tour of the Living Cell, Volume 2 by ChristiandeDuve Mathematics and Optimal Form by Stefan Hildebrandt [de] Fire by...
phagocytes, it is first discovered in rat hepatocytes by cell biologist ChristiandeDuve. Autophagosomes have a double membrane, the inner one from the engulfed...
Antony Hewish Chemistry – Paul J. Flory Medicine – Albert Claude, ChristiandeDuve, George Emil Palade Turing Award – Donald Knuth March 10 – Biz Stone...
Baptiste Carnoy Peter Agre Günter Blobel Robert Brown Geoffrey M. Cooper ChristiandeDuve Henri Dutrochet Robert Hooke H. Robert Horvitz Marc Kirschner Anton...
Sciences. In 1951, together with Edouard J. Bigwood, Jean Brachet, ChristiandeDuve, Marcel Florkin, Paul Putzeys, Laurent Vandendriessche and Claude...
theologians and philosophers, including Alan Guth, John Searle, ChristiandeDuve, and Nobel Prize-winner Steven Weinberg. The conference brought things...
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