Crystal structure of chorismate mutase with a transition state analogue bound
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EC no.
5.4.99.5
CAS no.
9068-30-8
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In enzymology, chorismate mutase (EC 5.4.99.5) is an enzyme that catalyzes the chemical reaction for the conversion of chorismate to prephenate in the pathway to the production of phenylalanine and tyrosine, also known as the shikimate pathway.
Hence, this enzyme has one substrate, chorismate, and one product, prephenate. Chorismate mutase is found at a branch point in the pathway. The enzyme channels the substrate, chorismate to the biosynthesis of tyrosine and phenylalanine and away from tryptophan.[1] Its role in maintaining the balance of these aromatic amino acids in the cell is vital.[2] This is the single known example of a naturally occurring enzyme catalyzing a pericyclic reaction.[2][nb 1] Chorismate mutase is only found in fungi, bacteria, and higher plants. Some varieties of this protein may use the morpheein model of allosteric regulation.[4]
^Qamra R, Prakash P, Aruna B, Hasnain SE, Mande SC (June 2006). "The 2.15 A crystal structure of Mycobacterium tuberculosis chorismate mutase reveals an unexpected gene duplication and suggests a role in host-pathogen interactions". Biochemistry. 45 (23): 6997–7005. doi:10.1021/bi0606445. PMID 16752890.
^ abKast P, Grisostomi C, Chen IA, Li S, Krengel U, Xue Y, Hilvert D (November 2000). "A strategically positioned cation is crucial for efficient catalysis by chorismate mutase". The Journal of Biological Chemistry. 275 (47): 36832–8. doi:10.1074/jbc.M006351200. PMID 10960481.
^Luk LY, Qian Q, Tanner ME (August 2011). "A cope rearrangement in the reaction catalyzed by dimethylallyltryptophan synthase?". Journal of the American Chemical Society. 133 (32): 12342–5. doi:10.1021/ja2034969. PMID 21766851.
^Selwood T, Jaffe EK (March 2012). "Dynamic dissociating homo-oligomers and the control of protein function". Archives of Biochemistry and Biophysics. 519 (2): 131–43. doi:10.1016/j.abb.2011.11.020. PMC 3298769. PMID 22182754.
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In enzymology, chorismatemutase (EC 5.4.99.5) is an enzyme that catalyzes the chemical reaction for the conversion of chorismate to prephenate in the...
transformed into chorismate by a chorismate synthase. Prephenic acid is then synthesized by a Claisen rearrangement of chorismate by chorismatemutase. Prephenate...
transformed into chorismate by a chorismate synthase. Prephenic acid is then synthesized by a Claisen rearrangement of chorismate by chorismatemutase. Prephenate...
under mild conditions. The enzyme chorismatemutase (EC 5.4.99.5) catalyzes the Claisen rearrangement of chorismate to prephenate, an intermediate in...
is mediated by a phenylalanine (PheA) or tyrosine (TyrA) specific chorismatemutase-prephenate dehydrogenase. PheA uses a simple dehydrogenase to convert...
stereochemistry at the third carbon. Chorismatemutase is an intramolecular transferase and it catalyzes the conversion of chorismate to prephenate, used as a precursor...
lymphocytes in response to pathogens to trigger the immune system. Chorismatemutase (right) catalyzes (speeds up) the production of the amino acids phenylalanine...
phosphoenol pyruvate. The enzyme chorismatemutase catalyzes the Claisen rearrangement of the enol ether called chorismate to prephenate, an intermediate...
a structural homolog of the chorismatemutase enzyme in E. coli, and actually exhibits non-physiological chorismatemutase activity, albeit at a much lower...
various enzymes derived from the shikimic-chorismic acid pathway. Chorismatemutase then converts chorismic acid to prephenate via a Claisen rearrangement...
epiprephenic. C10H10O6 Helmut Goerisch (1978). "On the mechanism of the chorismatemutase reaction". Biochemistry. 17 (18): 3700–3705. doi:10.1021/bi00611a004...
pathway. In the synthesis of L-phenylalanine, chorismate undergoes a Claisen rearrangement by a Chorismatemutase enzyme to form prephenate. Prephenate undergoes...
amino acid. One project demonstrated that an engineered version of Chorismatemutase still had catalytic activity when only nine amino acids were used...
Hydroxyphenylpyruvate synthase may refer to: Prephenate dehydrogenase, an enzyme Chorismatemutase, an enzyme This set index page lists enzyme articles associated with...
Other names in common use include hydroxyphenylpyruvate synthase, and chorismatemutase---prephenate dehydrogenase. This enzyme participates in phenylalanine...
named after three of the proteins that contain it: aspartate kinase, chorismatemutase and TyrA. The archetypical ACT domain is the C-terminal regulatory...
transfers the hydroxy group of chorismate between carbons. Isochorismate synthase catalyzes the irreversible conversion of chorismate to isochorismate: Isochorismate...
N-terminal transit peptide, a PDT-like domain, and an ACT (Aspartokinase, chorismatemutase, TyrA) domain. Homologues for ADT have been isolated in Arabidopsis...
putative effector proteins that may alter the host defense mechanism: chorismatemutase (CM) and isochorismatase (ICM), thought to be interfering on the salicylic...
development of a new class of antibiotics as the compound clings to the chorismatemutase enzyme in the shikimate pathway which assists in the synthesis of...
Nocardia mediterranei 1994 Cloning vector system for Nocardia spp 1995 Chorismatemutase and 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the methylotrophic...
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