Cholesterol oleate, a member of the cholesteryl ester family
Cholesteryl ester, a dietary lipid, is an ester of cholesterol. The ester bond is formed between the carboxylate group of a fatty acid and the hydroxyl group of cholesterol. Cholesteryl esters have a lower solubility in water due to their increased hydrophobicity. Esters are formed by replacing at least one –OH (hydroxyl) group with an –O–alkyl (alkoxy) group. They are hydrolyzed by pancreatic enzymes, cholesterol esterase, to produce cholesterol and free fatty acids.[1] They are associated with atherosclerosis.[2]
Cholesteryl ester is found in human brains as lipid droplets which store and transport cholesterol.[3] Increased levels of cholesteryl ester have been found in certain parts of the brain of people with Huntington disease. Higher concentrations of cholesteryl ester have been found in the caudate and putamen, but not the cerebellum, of people with Huntington disease compared with levels in controls.[4] Increase in cholesteryl ester has also been found in other neurological disorders like multiple sclerosis and Alzheimer's disease.[3]
^Ferrier, Richard A. Harvey, Denise R. (2011). Lippincott's illustrated reviews, biochemistry (5th ed.). Philadelphia: Wolters Kluwer Health. p. 175. ISBN 9781608314126.{{cite book}}: CS1 maint: multiple names: authors list (link)
^Cholesterol+Esters at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
^ abPhillips, Gabrielle R.; Hancock, Sarah E.; Brown, Simon H. J.; Jenner, Andrew M.; Kreilaus, Fabian; Newell, Kelly A.; Mitchell, Todd W. (2020-11-20). "Cholesteryl ester levels are elevated in the caudate and putamen of Huntington's disease patients". Scientific Reports. 10 (1): 20314. Bibcode:2020NatSR..1020314P. doi:10.1038/s41598-020-76973-8. ISSN 2045-2322. PMC 7680097. PMID 33219259.
^"Illawarra Health and Medical Research Institute Researchers Report on Findings in Huntington Disease (Cholesteryl ester levels are elevated in the caudate and putamen of Huntington's disease patients) (Cholesteryl ester levels are elevated in ...)." Obesity, Fitness & Wellness Week, 2020, p. 2684. Gale Academic OneFile, link.gale.com/apps/doc/A643924682/AONE?u=cuny_hunter&sid=AONE&xid=6782d457. Accessed 2 May 2021.
Cholesterylester, a dietary lipid, is an ester of cholesterol. The ester bond is formed between the carboxylate group of a fatty acid and the hydroxyl...
Cholesterylester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl...
enzyme synthesizes acetyl-CoA using citrate from the mitochondria. Cholesterylester transfer protein (CETP) inhibitors include the agents torcetrapib...
carboxylic ester bonds. The systematic name is steryl-ester acylhydrolase. Other names in common use include cholesterol esterase, cholesterylester synthase...
This enzyme plays an important role in breaking down fatty material (cholesterylesters and triglycerides) in the body. Infants, children and adults that...
for those most at risk: men over the age of 65. Anacetrapib is a cholesterylester transfer protein inhibitor that raises high-density lipoprotein (HDL)...
Cholesteryl nonanoate, also called cholesteryl pelargonate, 3β-cholest-5-en-3-ol nonaoate or cholest-5-ene-3-β-yl nonanoate, is an ester of cholesterol...
"Raising high-density lipoprotein in humans through inhibition of cholesterylester transfer protein: an initial multidose study of torcetrapib". Arteriosclerosis...
hydrolysis of fats. Some lipases display broad substrate scope including esters of cholesterol, phospholipids, and of lipid-soluble vitamins and sphingomyelinases;...
transfer inhibit protein to inhibit cholesterylester transfer protein-mediated transfers of cholesterylesters and triglycerides. Apolipoprotein M (apoM)...
Cholesteryl benzoate, also called 5-cholesten-3-yl benzoate, is an organic chemical, an ester of cholesterol and benzoic acid. It is a liquid crystal...
animals, cholesterylester transfer protein, also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters...
blood lipids of (relatively) cis and trans fat rich meals showed that cholesterylester transfer (CET) was 28% higher after the trans meal than after the...
applicated and tested into buildings, are the leuco dyes . "Preparation of CholesterylEster Liquid Crystals". Seeboth, Arno and Lötzsch, Detlef (2014) Thermochromic...
groups. The simple lipids are then divided further into glycerides, cholesterylesters, and waxes. The term was first used by T. P. Hidlich [de] in 1947...
them soluble in the salt-water-based blood pool. Triglycerides and cholesterylesters are carried internally, shielded from the water by the outer shell...
storage diseases Type II Pompe disease Type IIb Danon disease Other Cholesterylester storage disease Lysosomal disease The symptoms of lysosomal storage...
cassette transporter A1 is a key molecule in high-density lipoprotein cholesterylester metabolism in mice". Arteriosclerosis, Thrombosis, and Vascular Biology...
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