Certolizumab pegol, sold under the brand name Cimzia, is a biopharmaceutical medication for the treatment of Crohn's disease,[2][3] rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. It is a fragment of a monoclonal antibody specific to tumor necrosis factor alpha (TNF-α) and is manufactured by UCB.[4][5][6]
It is on the World Health Organization's List of Essential Medicines.[7]
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved October 22, 2023.
^Sandborn WJ, Feagan BG, Stoinov S, Honiball PJ, Rutgeerts P, Mason D, et al. (July 2007). "Certolizumab pegol for the treatment of Crohn's disease". The New England Journal of Medicine. 357 (3): 228–238. doi:10.1056/NEJMoa067594. PMID 17634458.
^Goel N, Stephens S (2010). "Certolizumab pegol". mAbs. 2 (2): 137–147. doi:10.4161/mabs.2.2.11271. PMC 2840232. PMID 20190560.
^"Drug Approval Package: Cimzia (Certolizumab Pegol) NDA #125160". U.S. Food and Drug Administration (FDA). December 24, 1999. Retrieved July 18, 2020.
^"Cimzia- certolizumab pegol kit Cimzia- certolizumab pegol injection, solution". DailyMed. April 24, 2020. Retrieved July 18, 2020.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
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the best selling drug in 2017 with sales upwards of $18 billion. Certolizumabpegol is a recombinant antigen-binding fragment antibody that is attached...
are TNF-α inhibitors, including infliximab, etanercept, golimumab, certolizumabpegol and adalimumab, as well as the IL-12/IL-23 inhibitor ustekinumab,...
monoclonal antibodies targeting TNF-α are golimumab, adalimumab, and certolizumabpegol. Etanercept also binds and inhibits the action of TNF-α, but is not...
infliximab (Remicade) binding directly to TNF, adalimumab (Humira), certolizumabpegol (Cimzia) or with a decoy circulating receptor fusion protein such...
monoclonal antibodies (MAbs) (infliximab, adalimumab, golimumab, and certolizumabpegol) and one recombinant TNF-α decoy receptor, etanercept, have been developed...
is in development. For example, CDP870 was UCB's company code for certolizumabpegol; UCB later chose "Cimzia" as its trade name. Many of these codes,...
achieved with a monoclonal antibody such as infliximab, adalimumab, certolizumabpegol, and golimumab, or with a circulating receptor fusion protein such...
(Krystexxa) – PEGylated uricase for the treatment of gout (Savient, 2010) Certolizumabpegol (Cimzia) – monoclonal antibody for treatment of moderate to severe...
cause confusion in prescribing and dispensing and should be avoided. Certolizumabpegol, etanercept, golimumab and infliximab are alternatives, including...
formula C2115H3252N556O673S16 (molar mass: 47,750 g/mol) may refer to: Certolizumabpegol Lumiliximab This set index page lists chemical structure articles...
TNFi treatment. Unlike other TNFi treatments such as adalimumab and certolizumabpegol, there have been no reported cases of drug-induced lupus-like syndrome...
Vencovský, J.; Heijde, D. van der (June 1, 2009). "Efficacy and safety of certolizumabpegol plus methotrexate in active rheumatoid arthritis: the RAPID 2 study...
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