Carboxylesterase 3 information

CES3
Identifiers
Aliases	CES3, ES31, carboxylesterase 3
External IDs	OMIM: 605279; MGI: 102773; HomoloGene: 84407; GeneCards: CES3; OMA:CES3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	66,975,149 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	105,785,045 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; right lobe of liver; ; mucosa of sigmoid colon; ; mucosa of ileum; ; muscle of thigh; ; gastrocnemius muscle; ; jejunal mucosa; ; duodenum; ; tendon of biceps brachii;
	Top expressed in
	hepatobiliary system; ; liver; ; duodenum; ; proximal tubule; ; pancreas; ; colon; ; ileum; ; jejunum; ; spermatid; ; testicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; carboxylic ester hydrolase activity; sterol esterase activity; triglyceride lipase activity; methyl indole-3-acetate esterase activity;
Cellular component	endoplasmic reticulum lumen; endoplasmic reticulum; extracellular exosome; cytosol; extracellular space;
Biological process	xenobiotic metabolic process; low-density lipoprotein particle clearance; lipid catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	23491
	382053
	ENSG00000172828
	ENSMUSG00000069922
	Q6UWW8
	Q63880
	NM_001185176; NM_001185177; NM_012122; NM_024922
	NM_001164681; NM_198672
	NP_001172105; NP_001172106; NP_079198
	NP_001158153; NP_941074
	Wikidata
View/Edit Human	View/Edit Mouse

Carboxylesterase 3 is an enzyme that in humans is encoded by the CES3 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172828 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000069922 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mori M, Hosokawa M, Ogasawara Y, Tsukada E, Chiba K (Oct 1999). "cDNA cloning, characterization and stable expression of novel human brain carboxylesterase". FEBS Lett. 458 (1): 17–22. doi:10.1016/S0014-5793(99)01111-4. PMID 10518925. S2CID 5792413.
^ Sanghani SP, Quinney SK, Fredenburg TB, Sun Z, Davis WI, Murry DJ, Cummings OW, Seitz DE, Bosron WF (Oct 2003). "Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis". Clin Cancer Res. 9 (13): 4983–91. PMID 14581373.
^ Sanghani SP, Quinney SK, Fredenburg TB, Davis WI, Murry DJ, Bosron WF (Apr 2004). "Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3". Drug Metab Dispos. 32 (5): 505–11. doi:10.1124/dmd.32.5.505. PMID 15100172.
^ "Entrez Gene: CES3 carboxylesterase 3 (brain)".

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