cholesterol ester hydrolysis involved in cholesterol transport
cholesterol biosynthetic process
medium-chain fatty acid metabolic process
lipid catabolic process
angiotensin maturation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1066
104158
Ensembl
ENSG00000198848 ENSG00000262243
ENSMUSG00000056973
UniProt
P23141
Q8VCT4
RefSeq (mRNA)
NM_001025194 NM_001025195 NM_001266
NM_053200
RefSeq (protein)
NP_001020365 NP_001020366 NP_001257
NP_444430
Location (UCSC)
Chr 16: 55.8 – 55.83 Mb
Chr 8: 93.89 – 93.92 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Liver carboxylesterase 1 also known as carboxylesterase 1 (CES1, hCE-1 or CES1A1) is an enzyme that in humans is encoded by the CES1 gene.[5][6] The protein is also historically known as serine esterase 1 (SES1), monocyte esterase and cholesterol ester hydrolase (CEH). Three transcript variants encoding three different isoforms have been found for this gene.[6] The various protein products from isoform a, b and c range in size from 568, 567 and 566 amino acids long, respectively.
CES1 is present in most tissues with higher levels in the liver and low levels in the gastrointestinal tract.[7]
^Imai T (Jun 2006). "Human Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design". Drug Metabolism and Pharmacokinetics. 21 (3): 173–185. doi:10.2133/dmpk.21.173. PMID 16858120.
and 25 Related for: Carboxylesterase 1 information
Liver carboxylesterase1 also known as carboxylesterase1 (CES1, hCE-1 or CES1A1) is an enzyme that in humans is encoded by the CES1 gene. The protein...
The enzyme carboxylesterase (or carboxylic-ester hydrolase, EC 3.1.1.1; systematic name carboxylic-ester hydrolase) catalyzes reactions of the following...
precursor drug, is converted to the active metabolite ramiprilat by carboxylesterase1. Ramiprilat is mostly excreted by the kidneys. Its half-life is variable...
yielding ritalinic acid. The hydrolysis was found to be catalyzed by carboxylesterase1 (CES1). Etymologically, ritalinic acid shares its roots with Ritalin...
Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene. It is a member of the alpha/beta fold hydrolase family. Carboxylesterase 2...
Carboxylesterase 3 is an enzyme that in humans is encoded by the CES3 gene. Carboxylesterase 3 is a member of a large multigene family. The enzymes encoded...
Prasugrel is a prodrug and is rapidly metabolized by carboxylesterase 2 in the intestine and carboxylesterase1 in the liver to a likewise inactive thiolactone...
cathepsin A or carboxylesterase1, followed by cleaving of the phosphoramidate by the enzyme histidine triad nucleotide-binding protein 1 (HINT1), and subsequent...
bioavailability, is hydrolyzed to a carboxylic acid, carotegrast, by the enzyme carboxylesterase1 in the liver. Carotegrast is an α4-integrin antagonist which prevents...
The chloride cocaine esterase (EC 3.1.1.84, CocE, hCE2, hCE-2, human carboxylesterase 2; systematic name cocaine benzoylhydrolase) catalyses the reaction...
activity serves to terminate synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus...
is hydrolyzed into its active metabolite SN-38 in the liver by two carboxylesterase converting enzymes (CES1 and CES2) and in plasma by butyrylcholinesterase...
Isocarboxazid to 1 product". go.drugbank.com. Retrieved 27 October 2021. Moroi K, Kuga T (April 1982). "Inhibitory effect of leptophos on carboxylesterase (isocarboxazid...
Carboxylesterase, type B is a family of evolutionarily related proteins that belongs to the superfamily of proteins with the Alpha/beta hydrolase fold...
Malathion resistance is thought to always be due to either increased carboxylesterase concentrations or altered acetylcholinesterases. COE because it metabolizes...
Cauxin is a carboxylesterase that is excreted in large amounts in cat urine. There is also evidence that it can serve as a peptide hydrolase in the production...
of 3143 mg/kg. In rodent models, butyl acrylate is metabolized by carboxylesterase or reactions with glutathione; this detoxification produces acrylic...
the consumed methylphenidate is converted to ethylphenidate. This carboxylesterase-dependent transesterification process is also known to occur when cocaine...
(August 2004). "Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1". The Journal of Pharmacology and Experimental Therapeutics...
desensitization, while organophosphate resistance most commonly is carboxylesterase metabolization. While the carbamate acetylcholinesterase inhibitors...
the liver by the metabolism of cocaine by hydrolysis, catalysed by carboxylesterases, and subsequently excreted in the urine. It is readily synthesised...
SAM-mediated O-methylation on C4′. The O-acetyl group is then cleaved by a carboxylesterase (CXE1), yielding an alcohol which immediately reacts with the neighboring...