The Cancer Genome Project is part of the cancer, aging, and somatic mutation research based at the Wellcome Trust Sanger Institute in the United Kingdom. It aims to identify sequence variants/mutations critical in the development of human cancers. Like The Cancer Genome Atlas project within the United States, the Cancer Genome Project represents an effort in the War on Cancer to improve cancer diagnosis, treatment, and prevention through a better understanding of the molecular basis of the disease. The Cancer Genome Project was launched by Michael Stratton in 2000, and Peter Campbell is now the group leader of the project. The project works to combine knowledge of the human genome sequence with high throughput mutation detection techniques.[1]
The project operates within the scope of the International Cancer Genome Consortium, working with the other participating organizations and countries to build a database of genomic changes present in different types of cancer.[2] The somatic mutation information gathered by the project can be located in the COSMIC database. The Wellcome Trust Sanger Institute's project currently has several internal partners that each focus on different types of cancer and mutagenesis utilizing different methods.[1][3] Research goes beyond just sequencing to include therapeutic biomarker discoveries made utilizing bioinformatics programs. Among these discoveries are drug sensitivity biomarkers and inhibitor biomarkers. These discoveries paired with the evolution of DNA sequencing technologies to next-generation sequencing techniques, are important in potential disease treatment and may even help lead to more personalized medicine for cancer patients.[4][5]
^ abhttp://www.sanger.ac.uk/research/faculty/pcampbell/ Peter Campbell
^Covell, David (2015). "Data Mining Approaches for Genomic Biomarker Development: Applications Using Drug Screening Data from the Cancer Genome Project and the Cancer Cell Line Encyclopedia". PLOS ONE. 10 (7): e0127433. Bibcode:2015PLoSO..1027433C. doi:10.1371/journal.pone.0127433. PMC 4489368. PMID 26132924.
^"The National Cancer Institute, Cancer Research UK, the Wellcome Trust Sanger Institute and the foundation Hubrecht Organoid Technology are to collaborate on the Human Cancer Models Initiative". Chemistry and Industry. 80 (7).
^Garnett, Mathew J.; Edelman, Elena J.; Heidorn, Sonja J.; Greenman, Chris D.; Dastur, Anahita; Lau, King Wai; Greninger, Patricia; Thompson, I. Richard; Luo, Xi (29 March 2012). "Systematic identification of genomic markers of drug sensitivity in cancer cells". Nature. 483 (7391): 570–575. Bibcode:2012Natur.483..570G. doi:10.1038/nature11005. ISSN 0028-0836. PMC 3349233. PMID 22460902.
^Garnett, Mathew J.; McDermott, Ultan (1 March 2012). "Exploiting genetic complexity in cancer to improve therapeutic strategies". Drug Discovery Today. Special Issue on Cancer Development. 17 (5–6): 188–193. doi:10.1016/j.drudis.2012.01.025. PMC 3672976. PMID 22342219.
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